Baldock G A, Brodie R R, Chasseaud L F, Taylor T
Department of Metabolism and Pharmacokinetics, Huntingdon Research Centre, Cambridgeshire, U.K.
J Chromatogr. 1990 Jul 13;529(1):113-23. doi: 10.1016/s0378-4347(00)83812-8.
A simple, sensitive and selective method for the determination of benzydamine in human plasma and urine, and for benzydamine N-oxide in urine, has been developed using high-performance liquid chromatography in the reversed-phase mode. The limit of reliable determination of benzydamine in plasma was 0.5 ng/ml and that in urine 1 ng/ml; the limit of reliable determination of benzydamine N-oxide in urine was 50 ng/ml. The method has been successfully applied to the analysis of these compounds in biological fluids after administration of intravenous and oral doses of benzydamine to human volunteers.
已开发出一种简单、灵敏且具选择性的方法，用于测定人血浆和尿液中的苄达明以及尿液中的苄达明N-氧化物，该方法采用反相高效液相色谱法。血浆中苄达明可靠测定的下限为0.5 ng/ml，尿液中为1 ng/ml；尿液中苄达明N-氧化物可靠测定的下限为50 ng/ml。该方法已成功应用于给人类志愿者静脉注射和口服苄达明后生物流体中这些化合物的分析。
