Blümcke I, Hamer H M
Neuropathologisches Institut, Universitätsklinikum Erlangen, Erlangen, Deutschland.
Nervenarzt. 2012 Feb;83(2):181-6. doi: 10.1007/s00115-011-3336-1.
In 2010 the International League against Epilepsy published a new classification of epilepsies. A major advance of this classification system is the acknowledgment of a genetic or pathologic-anatomic basis of epilepsy as important predictors of outcome (cause matters). This applies in particular to structural-metabolic lesions, which were frequently recognized in surgical specimens obtained from patients with drug-resistant focal epilepsy, i.e. hippocampal sclerosis, glioneuronal tumors, focal cortical dysplasias, vascular malformations, ischemia, intracerebral hemorrhage, glial scars or inflammation. A better understanding and classification of the etiopathology as well as the underlying molecular mechanisms will help to anticipate and appreciate the clinical course of a disease as well as to develop new and targeted drug treatment. Surgically available human brain tissue will be most helpful to support this approach but will also need careful neuropathological evaluation with accurate classification systems and use of terminology.
2010年，国际抗癫痫联盟发布了癫痫的新分类。该分类系统的一个主要进展是承认癫痫的遗传或病理解剖学基础是预后的重要预测因素（病因很重要）。这尤其适用于结构 - 代谢性病变，这些病变在耐药性局灶性癫痫患者的手术标本中经常被发现，即海马硬化、神经胶质神经元肿瘤、局灶性皮质发育异常、血管畸形、缺血、脑出血、胶质瘢痕或炎症。更好地理解和分类病因病理以及潜在的分子机制将有助于预测和了解疾病的临床过程，并开发新的靶向药物治疗。手术可获取的人脑组织将最有助于支持这种方法，但也需要使用准确的分类系统和术语进行仔细的神经病理学评估。
