Alberius P, Isaksson S, Klinge B, Sjögren S, Jönsson J
Dept. of Plastic Surgery, Sahlgrenska Hospital, Göteborg, Sweden.
J Craniomaxillofac Surg. 1990 Aug;18(6):271-9. doi: 10.1016/s1010-5182(05)80430-5.
The positioning of osteotomies in intramembranous cranial bone was studied by exploring the pattern of bone regeneration in growth areas (the sutural region) as compared to that of the bone plate proper. Trephine defects in the left coronal suture area and the right parietal bone were produced in fifty-nine young rabbits. A pilot study to refine operative and analytical methods comprised 22 animals. The experiments were terminated at one, three, and six weeks after surgery. The bone regenerative response was assessed by x-ray planimetry, plain microscopy, enzyme histochemistry, and fluorescent labelling. Only minor divergences in healing capacity between the two defects were found. No adverse effects on the growth process were indicated. As to clinical management, the findings suggest that osteotomies designed to traverse sutural areas will, under normal circumstances, regenerate in a similar manner and rate to adjoining bone plates.
通过探索生长区域（缝合区域）与骨板本身的骨再生模式，研究了膜内颅骨截骨术的定位。在59只幼兔身上制造了左冠状缝区域和右顶骨的环锯缺损。一项旨在完善手术和分析方法的初步研究包括22只动物。实验在术后1周、3周和6周结束。通过X线平面测量、普通显微镜检查、酶组织化学和荧光标记评估骨再生反应。发现两种缺损之间的愈合能力仅有微小差异。未显示对生长过程有不利影响。至于临床处理，研究结果表明，在正常情况下，设计穿过缝合区域的截骨术将以与相邻骨板相似的方式和速度再生。
