Brownstein C N, Briggs S D, Schweitzer K L, Briner W W, Kornman K S
Department of Periodontics, University of Texas Health Science Center, San Antonio 78284.
J Clin Periodontol. 1990 Sep;17(8):588-93.
This study compared oral irrigation and rinsing with chlorhexidine (CHX) and placebo in the treatment of naturally occurring chronic gingivitis. 44 subjects with at least 6 interproximal sites which bled on probing were randomly distributed on a double-blind basis into 4 treatment groups, placebo-rinse, CHX-rinse (0.12%), placebo-irrigation and CHX-irrigation (0.06%). A half-mouth was scaled 2 weeks prior to therapy in all groups. Rinses were performed 2 times daily and irrigation was performed once a day by means of an oral irrigator with the tip directed at a right angle to the tooth. Subjects continued with routine oral hygiene without instruction. The active treatment period was 2 months. Parameters were recorded at baseline and at 60 days. At the conclusion, marginal plaque was cultured for predominant microbial types. CHX-rinse (0.12%) and CHX-irrigation (0.06%) significantly reduced (p less than 0.05) plaque. Gingival bleeding decreased by 26% in both scaled and unscaled sites following CHX (0.12%) rinses and by 40% at both types of sites following CHX (0.06%) irrigation. Bleeding was reduced with CHX-irrigation greater (p less than 0.05) than with the placebo-irrigation. The mean log of colony-forming units of Actinomyces species was significantly lower (p less than 0.05) in the CHX (0.12%) rinse and CHX (0.06%) irrigator groups than in the placebo groups. These data therefore indicate that delivery of CHX (0.06%) by an oral irrigator is an effective means of treating naturally occurring gingivitis.
本研究比较了使用氯己定(CHX)和安慰剂进行口腔冲洗及漱口对自然发生的慢性牙龈炎的治疗效果。44名至少有6个探诊出血的邻面部位的受试者被双盲随机分为4个治疗组,即安慰剂漱口组、CHX漱口组(0.12%)、安慰剂冲洗组和CHX冲洗组(0.06%)。所有组在治疗前2周对半口牙齿进行洁治。每天漱口2次,使用口腔冲洗器每天冲洗1次,冲洗器喷头与牙齿呈直角。受试者在无指导的情况下继续进行常规口腔卫生护理。积极治疗期为2个月。在基线和60天时记录各项参数。研究结束时,对边缘菌斑进行主要微生物类型培养。CHX漱口组(0.12%)和CHX冲洗组(0.06%)显著减少了菌斑(p<0.05)。CHX(0.12%)漱口后,已洁治和未洁治部位的牙龈出血均减少了26%,CHX(0.06%)冲洗后,这两种部位的牙龈出血均减少了40%。CHX冲洗比安慰剂冲洗更能有效减少出血(p<0.05)。CHX(0.12%)漱口组和CHX(0.06%)冲洗组中放线菌属的平均菌落形成单位对数显著低于安慰剂组(p<0.05)。因此,这些数据表明,使用口腔冲洗器输送CHX(0.06%)是治疗自然发生的牙龈炎的有效方法。