Cusan L, Dupont A, Bélanger A, Tremblay R R, Manhes G, Labrie F
Laboratory of Molecular Endocrinology, Centre Hospitalier de l'Université Laval Research Center, Quebec, Canada.
J Am Acad Dermatol. 1990 Sep;23(3 Pt 1):462-9. doi: 10.1016/0190-9622(90)70241-9.
The effectiveness of the antiandrogen flutamide in combination with an oral contraceptive was studied in 20 patients with moderate to severe hirsutism. Eight patients had no previous therapy, whereas 12 had failed to respond to oral contraceptives, spironolactone, or dexamethasone therapy. Treatment with the antiandrogen flutamide (250 mg twice daily) and an oral contraceptive (Ortho 1/35) resulted in a particularly rapid and marked decrease in the total hirsutism score, which reached the normal range at 7 months. Seborrhea, acne, and hair loss score were also rapidly corrected. Treatment was associated with a decrease in plasma luteinizing hormone, progesterone, and estradiol levels. Plasma sex hormone-binding globulin levels were initially low in 18 to 20 patients but increased significantly during therapy. No clinically significant side effects were observed.
在20例中度至重度多毛症患者中研究了抗雄激素氟他胺与口服避孕药联合使用的效果。8例患者此前未接受过治疗，而12例患者对口服避孕药、螺内酯或地塞米松治疗无反应。使用抗雄激素氟他胺（每日两次，每次250毫克）和口服避孕药（炔诺酮/炔雌醇片）进行治疗后，多毛症总分出现了特别迅速且显著的下降，在7个月时达到正常范围。皮脂溢、痤疮和脱发评分也迅速得到改善。治疗与血浆促黄体生成素、孕酮和雌二醇水平降低有关。18至20例患者的血浆性激素结合球蛋白水平最初较低，但在治疗期间显著升高。未观察到具有临床意义的副作用。
