Cesur V, Kamel N, Uysal A R, Erdoğan G, Başkal N
Department of Endocrinology and Metabolic Diseases, Ankara University Medical School, Turkey.
Endocr J. 1994 Oct;41(5):573-7. doi: 10.1507/endocrj.41.573.
In this study the efficacy of flutamide, an antiandrogen which does not have a steroid structure, or progestational and estrogenic activities, on hirsutism and hormone levels in polycystic ovary syndrome (PCOS) and idiopathic hirsutism (IH) was investigated. Ten patients with PCOS and nine patients with IH between 19 and 36 years of age were selected for the study. They were given a 500 mg daily dose of flutamide and were followed up for clinical and hormonal effects at the second, sixth, eighth and twelfth months of the treatment. The severity of hirsutism was assessed according to the Ferriman-Gallwey's score. There was a slight decrease to below the pre-treatment level in serum LH at the end of the eighth month (P < 0.05) and there was also a persistent decrease in progesterone (P) after the second month of the treatment (P < 0.05). No other significant change was observed in ovarian or adrenal androgens. Clinical examinations revealed that after six months of the therapy the dose of flutamide had caused a significant alleviation of hirsutism and this continued during the following months.
在本研究中，对一种不具有类固醇结构、孕激素及雌激素活性的抗雄激素药物氟他胺治疗多囊卵巢综合征（PCOS）和特发性多毛症（IH）患者的多毛症及激素水平的疗效进行了研究。选取了10例年龄在19至36岁之间的PCOS患者和9例IH患者进行研究。给予他们每日500毫克的氟他胺剂量，并在治疗的第2、6、8和12个月对临床及激素效应进行随访。根据费里曼 - 盖尔韦评分评估多毛症的严重程度。在第8个月末，血清促黄体生成素（LH）略有下降至治疗前水平以下（P < 0.05），并且在治疗第2个月后孕酮（P）也持续下降（P < 0.05）。未观察到卵巢或肾上腺雄激素有其他显著变化。临床检查显示，治疗6个月后，氟他胺剂量已使多毛症明显减轻，且在随后几个月中持续改善。
