Chemistry, School of PEMS, University of New South Wales at ADFA, Australian Defence Force Academy, Canberra, ACT 2600, Australia.
J Org Chem. 2012 Jan 6;77(1):606-11. doi: 10.1021/jo2021778. Epub 2011 Dec 12.
The synthesis of the first family of fully substituted cucurbit[n]uril is discussed, and the structural features of precursor glycolurils are highlighted in their importance to achieving higher homologues. The members of the family, where n = 5-7, have been fully characterized, and increased binding affinities have been identified for dioxane in CyP(6)Q[6] and adamantyl NH(3)(+) in CyP(7)Q[7]. A higher homologue is indicated but not conclusively identified.
本文讨论了第一类全取代葫芦脲的合成，并强调了前体甘脲的结构特征在合成更高同系物中的重要性。该家族的成员（n = 5-7）已被全面表征，并确定了二氧六环在 CyP(6)Q[6]中的结合亲和力增加，以及金刚烷基 NH(3)(+)在 CyP(7)Q[7]中的结合亲和力增加。虽然表明存在更高同系物，但尚未明确鉴定。
