Jon Sang Yong, Selvapalam Narayanan, Oh Dong Hyun, Kang Jin-Koo, Kim Soo-Young, Jeon Young Jin, Lee Jae Wook, Kim Kimoon
National Creative Research Initiative Center for Smart Supramolecules and Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
J Am Chem Soc. 2003 Aug 27;125(34):10186-7. doi: 10.1021/ja036536c.
A long-standing problem in cucurbituril chemistry is answered through the first direct functionalization of cucurbit[n]uril (CB[n]; n = 5-8)) leading to perhydroxyCB[n] which can be further modified to provide tailored CB[n] derivatives with desired functional groups and good solubility. Anchoring a CB[6] derivative on the surface and its potential application as a sensor are demonstrated. A CB[6] derivative forms nanospheres with possible use in protein and peptide drug delivery.
葫芦脲化学领域一个长期存在的问题通过葫芦[n]脲（CB[n]；n = 5 - 8）的首次直接官能团化得到了解决，该官能团化反应生成了全羟基化的CB[n]，其可进一步修饰以提供具有所需官能团和良好溶解性的定制CB[n]衍生物。展示了将一种CB[6]衍生物锚定在表面及其作为传感器的潜在应用。一种CB[6]衍生物形成了纳米球，可能用于蛋白质和肽类药物递送。
