骨关节炎性膝关节伴与不伴积液的生化比较。
Biochemical comparison of osteoarthritic knees with and without effusion.
机构信息
Department of Sports Medicine, West Chester University of Pennsylvania, 19383, USA.
出版信息
BMC Musculoskelet Disord. 2011 Nov 28;12:273. doi: 10.1186/1471-2474-12-273.
BACKGROUND
Several symptom-relieving interventions have been shown to be efficacious among osteoarthritis (OA) patients with knee effusion; however, not every symptomatic knee OA patient has clinical effusion. Results may be over-generalized since it is unclear if effused knees represent a unique pathological condition or subset compared to knees without effusion. The primary purpose of this study was to determine if biochemical differences existed between OA knees with and without effusion.
METHODS
The present cross-sectional study consisted of 22 volunteers (11 with knee effusion, 11 without knee effusion) with confirmed late-stage radiographic knee OA (Kellgren-Lawrence score ≥ 3). Synovial fluid samples were collected and analyzed using a custom multiplex enzyme-linked immunosorbent assay to determine eight specific biomarker concentrations (e.g., catabolic, anabolic).
RESULTS
Matrix metalloproteinase (MMP)-3, tissue inhibitor of MMPs (TIMP)-1, TIMP-2, and interleukin-10 were significantly higher in the knees with effusion than in the knees without effusion.
CONCLUSIONS
The biochemical differences that existed between knees with and without effusion provide support that OA subsets may exist, characterized by distinct biochemical characteristics and clinical findings (e.g., effusion).
背景
多项缓解症状的干预措施已被证实对膝关节有积液的骨关节炎（OA）患者有效；然而，并非每个有症状的膝关节 OA 患者都有临床积液。由于尚不清楚有积液的膝关节与无积液的膝关节相比是否代表一种独特的病理状况或亚组，因此结果可能被过度推广。本研究的主要目的是确定有和无积液的 OA 膝关节之间是否存在生化差异。
方法
本横断面研究包括 22 名志愿者（11 名膝关节有积液，11 名膝关节无积液），均确诊为晚期放射学膝关节 OA（Kellgren-Lawrence 评分≥3）。采集滑膜液样本，并使用定制的多重酶联免疫吸附试验进行分析，以确定 8 种特定生物标志物的浓度（例如，分解代谢物、合成代谢物）。
结果
有积液的膝关节中的基质金属蛋白酶（MMP）-3、基质金属蛋白酶抑制剂（TIMP）-1、TIMP-2 和白细胞介素-10 明显高于无积液的膝关节。
结论
有和无积液的膝关节之间存在的生化差异支持 OA 亚组可能存在，其特征是具有独特的生化特征和临床发现（例如积液）。
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