白细胞介素-13 和白细胞介素-17A 基因多态性在日本阿司匹林加重性呼吸道疾病患者中的研究。

IL-13 and IL-17A gene polymorphisms in Japanese patients with aspirin-exacerbated respiratory disease.

机构信息

Gunma Institute for Allergy and Asthma, Gunma Hospital for Allergic and Respiratory Diseases, Ohra-machi, Gunma, Japan.

出版信息

Ann Allergy Asthma Immunol. 2011 Dec;107(6):510-6. doi: 10.1016/j.anai.2011.09.003. Epub 2011 Sep 22.

DOI:10.1016/j.anai.2011.09.003

PMID:22123380

Abstract

BACKGROUND

The role of interleukin (IL) 13 and IL-17A in aspirin-exacerbated respiratory disease (AERD) remains unknown.

OBJECTIVE

To analyze the IL-13 and IL-17A gene polymorphisms in Japanese patients with AERD.

METHODS

The single-nucleotide polymorphisms in each gene were examined in patients with AERD, patients with aspirin-tolerant asthma (ATA), and healthy controls.

RESULTS

Frequencies of the TT/CT genotype of the IL-13 -1111C>T gene were higher than frequencies of the CC genotype in AERD patients compared with ATA patients (P < .001). In female patients with AERD, frequencies of the TT/CT genotype were higher than those of the CC genotype compared with female patients with ATA (P < .001). However, genotype frequencies of IL-13 Arg110Gln did not differ between AERD and ATA patients. Frequencies of the CC genotype of the IL-17A -737C>T gene were higher than those of the TT/CT genotype in AERD patients compared with ATA patients (P = .02). In female patients with AERD, frequencies of the CC genotype were higher than those of the TT/CT genotype compared with female patients with ATA (P = .03). Forced expiratory volume in 1 second (percentage predicted) in AERD patients with the CC genotype of the IL-13 -1111C>T gene was lower than that in the patients with the TT/CT genotype. AERD patients with the TT/CT genotype of the IL-17A -737C>T gene had a higher peripheral total eosinophil count compared with the patients with the CC genotype. The comparison of the clinical characteristics according to the IL-13 Arg110Gln gene polymorphism showed no difference.

CONCLUSIONS

These findings suggest that the IL-13 -1111C>T and IL-17A -737C>T gene sequence variations might have a role in the development of AERD.

摘要

背景

白细胞介素（IL）13 和 IL-17A 在阿司匹林加重性呼吸系统疾病（AERD）中的作用尚不清楚。

目的

分析日本 AERD 患者的 IL-13 和 IL-17A 基因多态性。

方法

在 AERD 患者、阿司匹林耐受型哮喘（ATA）患者和健康对照者中，检测了每个基因的单核苷酸多态性。

结果

与 ATA 患者相比，AERD 患者中 IL-13-1111C>T 基因 TT/CT 基因型的频率高于 CC 基因型（P<0.001）。在 AERD 女性患者中，与 ATA 女性患者相比，TT/CT 基因型的频率高于 CC 基因型（P<0.001）。然而，IL-13Arg110Gln 基因型的频率在 AERD 和 ATA 患者之间没有差异。与 ATA 患者相比，AERD 患者中 IL-17A-737C>T 基因 CC 基因型的频率高于 TT/CT 基因型（P=0.02）。在 AERD 女性患者中，与 ATA 女性患者相比，CC 基因型的频率高于 TT/CT 基因型（P=0.03）。与 TT/CT 基因型的 AERD 患者相比，IL-13-1111C>T 基因 CC 基因型的患者的 1 秒用力呼气量（百分比预计值）较低。IL-17A-737C>T 基因 TT/CT 基因型的 AERD 患者的外周血总嗜酸性粒细胞计数较高。根据 IL-13Arg110Gln 基因多态性比较临床特征，无差异。