Kim Sung-Dong, Cho Kyu-Sup
Department of Otorhinolaryngology-Head and Neck Surgery and Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
Clin Exp Otorhinolaryngol. 2018 Jun;11(2):71-80. doi: 10.21053/ceo.2017.01606. Epub 2018 Apr 13.
Samter's triad (ST) is a well-known disease characterized by the triad of bronchial asthma, nasal polyps, and aspirin intolerance. Over the past few years, a rapid development in the knowledge of the pathogenesis and clinical characteristics of ST has happened. The aim of this paper is to review the recent investigations on the pathophysiological mechanisms and genetic background, diagnosis, and different therapeutic options of ST to advance our understanding of the mechanism and the therapeutic control of ST. As concern for ST increase, more application of aspirin desensitization will be required to manage this disease successfully. There is also a need for continued research efforts in pathophysiology, treatment, and possible prevention.
桑特三联征（ST）是一种以支气管哮喘、鼻息肉和阿司匹林不耐受三联征为特征的知名疾病。在过去几年中，人们对ST的发病机制和临床特征的认识有了快速发展。本文旨在综述ST的病理生理机制、遗传背景、诊断及不同治疗选择的最新研究，以增进我们对ST机制和治疗控制的理解。随着对ST关注度的增加，成功管理该疾病将需要更多地应用阿司匹林脱敏治疗。在病理生理学、治疗及可能的预防方面也需要持续的研究努力。
