Koblet H, Wyler R, Kohler U
Experientia. 1979 May 15;35(5):575-6. doi: 10.1007/BF01960326.
Some effects of cAMP on replication of Semliki Forest Virus in chick embryo fibroblast cell cultures are described. Depending on concentration, the incorporation of [3H]-uridine into viral RNA or the formation of plaque-forming units is inhibited; the highest concentration tested was 8 mM. Cyclic AMP has an effect of its own and increases the Interferon action in the lower concentration ranges of Interferon (up to 1 unit/ml). The effect of cyclic AMP is fast, needs no induction and is also visible in late phases of viral replication. However, these experiments do not establish a causal relation between cAMP and Interferon.
本文描述了环磷酸腺苷（cAMP）对鸡胚成纤维细胞培养物中Semliki森林病毒复制的一些影响。根据浓度不同，[3H] - 尿苷掺入病毒RNA或噬斑形成单位的形成受到抑制；测试的最高浓度为8 mM。环磷酸腺苷有其自身的作用，并且在较低浓度范围的干扰素（高达1单位/毫升）中可增强干扰素的作用。环磷酸腺苷的作用迅速，无需诱导，在病毒复制的后期阶段也可见到。然而，这些实验并未确立环磷酸腺苷与干扰素之间的因果关系。
