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输入虫媒病毒核糖核酸的膜结合:干扰素或环己酰亚胺的作用

Membrane binding of input arbovirus ribonucleic acid: effect of interferon or cycloheximide.

作者信息

Friedman R M, Sreevalsan T

出版信息

J Virol. 1970 Aug;6(2):169-75. doi: 10.1128/JVI.6.2.169-175.1970.

Abstract

By 1 hr after infection, 36% of input Semliki Forest virus ribonucleic acid (RNA) which was cell associated was found in a membrane structure. This structure had many similarities to the membrane-associated replication complex (MRC) which had previously been identified in arbovirus infections. Interferon treatment did not affect the association of viral RNA with the MRC structure, but cycloheximide treatment inhibited it.

摘要

感染后1小时,与细胞相关的输入性塞姆利基森林病毒核糖核酸(RNA)中有36%存在于一种膜结构中。这种结构与先前在虫媒病毒感染中鉴定出的膜相关复制复合体(MRC)有许多相似之处。干扰素处理不影响病毒RNA与MRC结构的结合,但放线菌酮处理会抑制这种结合。

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本文引用的文献

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Purification, size, and morphology of a mosquitoborne animal virus, Semliki Forest virus.
Virology. 1961 May;14:124-31. doi: 10.1016/0042-6822(61)90139-8.
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Further purification of chick interferon.
Nature. 1965 Sep 18;207(5003):1298. doi: 10.1038/2071298a0.
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