新生儿脑膜炎相关大肠杆菌菌株 CE10 的全基因组序列。
Complete genome sequence of the neonatal-meningitis-associated Escherichia coli strain CE10.
机构信息
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy Medical Sciences & Peking Union Medical College, Beijing 100176, China.
出版信息
J Bacteriol. 2011 Dec;193(24):7005. doi: 10.1128/JB.06284-11.
Abstract
Neonatal bacterial meningitis continues to be an important cause of mortality and morbidity worldwide. Escherichia coli possessing the K1 capsular polysaccharide is the most common Gram-negative pathogen causing neonatal meningitis. Here we present the complete genome sequence of neonatal meningitis-associated E. coli strain CE10, a unique K1 strain with a functional type III secretion system. Functional analysis of the genome should enhance our knowledge of the pathogenesis of neonatal E. coli K1 meningitis.
摘要
新生儿细菌性脑膜炎仍然是全球范围内导致死亡率和发病率的重要原因。具有 K1 荚膜多糖的大肠杆菌是引起新生儿脑膜炎的最常见革兰氏阴性病原体。在这里，我们展示了与新生儿脑膜炎相关的大肠杆菌菌株 CE10 的完整基因组序列，这是一种具有功能性 III 型分泌系统的独特 K1 菌株。对基因组的功能分析应该增强我们对新生儿大肠杆菌 K1 脑膜炎发病机制的认识。
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