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一种与引起新生儿脑膜炎的大肠杆菌菌株紧密连锁的匿名分子标记物的特征分析。

Characterization of an anonymous molecular marker strongly linked to Escherichia coli strains causing neonatal meningitis.

作者信息

Clermont Olivier, Bonacorsi Stéphane, Bingen Edouard

机构信息

Laboratoire d'Etudes de Génétique Bactérienne dans les Infections de l'Enfant (EA3105), Université Denis Diderot-Paris 7, France.

出版信息

J Clin Microbiol. 2004 Apr;42(4):1770-2. doi: 10.1128/JCM.42.4.1770-1772.2004.

DOI:10.1128/JCM.42.4.1770-1772.2004
PMID:15071045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC387582/
Abstract

An anonymous 14.9-kb rrn-containing HindIII fragment is strongly linked to Escherichia coli strains causing neonatal meningitis. We show in this report that this fragment does not encode new virulence factors but lacks arpA, a gene common in avirulent E. coli strains, and we developed a PCR test to detect this fragment.

摘要

一个含有rrn的14.9千碱基对的匿名HindIII片段与引起新生儿脑膜炎的大肠杆菌菌株紧密相关。我们在本报告中表明，该片段不编码新的毒力因子，而是缺少无毒力大肠杆菌菌株中常见的arpA基因，并且我们开发了一种PCR检测方法来检测该片段。

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本文引用的文献

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Molecular analysis and experimental virulence of French and North American Escherichia coli neonatal meningitis isolates: identification of a new virulent clone.法国和北美大肠杆菌新生儿脑膜炎分离株的分子分析与实验毒力：一种新的强毒克隆的鉴定
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Phylogenetic distribution of virulence-associated genes among Escherichia coli isolates associated with neonatal bacterial meningitis in the Netherlands.荷兰新生儿细菌性脑膜炎相关大肠杆菌分离株中毒力相关基因的系统发育分布
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