合成具有光化学和荧光性质的二甲基马鞭草酚 B 的双标记探针。

Department of Chemistry, Yonsei University, Seoul 120-749, Korea.

Molecules. 2011 Nov 28;16(12):9886-99. doi: 10.3390/molecules16129886.

Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for biological application was evaluated by UV and fluorescence to determine its electrochemical absorption and emission properties. This probe could be valuable for investigating ligand-protein interactions and subcellular localization.

二甲基锂代白鲜交酯 B（DLB）是一种高效的天然抗氧化剂和抗糖尿病多酚，其作用模式未知。为了确定其细胞靶标，设计并高效合成了一种光化学和荧光二甲基锂代白鲜交酯 B 探针。通过紫外和荧光对双标记生物应用化学探针进行了评估，以确定其电化学吸收和发射特性。该探针对于研究配体-蛋白相互作用和亚细胞定位可能很有价值。