Mergener Michelle, Becker Roze Mary Ribas, dos Santos Adriana Freitag, dos Santos Geraldine Alves, de Andrade Fabiana Michelsen
Universidade Federal de Ciências da Saúde de Porto Alegre.
Rev Bras Reumatol. 2011 Dec;51(6):594-602.
This study aimed to investigate the genetic influence of the T102C polymorphism of the 2A serotonin receptor gene (HTR2A) and its interaction with environmental aspects, such as exposure to noise, traffic, climate, and opportunities to acquire new information, physical protection, and security, among others, as possible risk factors for developing fibromyalgia syndrome (FMS).
Forty-one FMS patients and 49 controls were evaluated. Environmental factors were evaluated by application of the V domain of the WHOQOL-100 questionnaire. Patients were asked that their answers represented only the periods preceding the onset of symptoms. The T102C variant of the HTR2A gene was determined through PCR/RFLP.
Among patients, the frequency of carriers of the 102C allele was higher than in controls (76.5% vs. 50%; P = 0.028). The scores of the V domain were lower in patients than in controls, indicating a worst perception of the environmental quality by patients (P < 0.001). The factor "lack of opportunities for acquiring new information and skills" increased the chance of developing FMS by almost 14-fold (P = 0.009). The factor "low quality of social care and health" together with the presence of the 102C allele also increased this chance by more than 90-fold (P = 0.005). However, carriers of the same allele who have high quality social care and health are not at a higher risk to develop FMS.
These data suggest that these factors may predispose to FMS, especially in carriers of the 102C allele. However, studies with larger samples are required to confirm this hypothesis.
本研究旨在调查2A血清素受体基因（HTR2A）的T102C多态性的遗传影响及其与环境因素的相互作用，如接触噪音、交通、气候以及获取新信息、身体保护和安全等机会，这些均可能是纤维肌痛综合征（FMS）发病的危险因素。
对41例FMS患者和49例对照进行评估。通过应用WHOQOL - 100问卷的V领域评估环境因素。要求患者的回答仅代表症状出现前的时期。通过PCR/RFLP确定HTR2A基因的T102C变体。
在患者中，102C等位基因携带者的频率高于对照组（76.5%对50%；P = 0.028）。患者的V领域得分低于对照组，表明患者对环境质量的感知更差（P < 0.001）。“缺乏获取新信息和技能的机会”这一因素使患FMS的几率增加了近14倍（P = 0.009）。“社会护理和健康质量低”这一因素与102C等位基因的存在一起也使患FMS的几率增加了90倍以上（P = 0.005）。然而，拥有高质量社会护理和健康的相同等位基因携带者患FMS的风险并不更高。
这些数据表明这些因素可能易患FMS，尤其是102C等位基因的携带者。然而，需要更大样本的研究来证实这一假设。
