Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Ann Surg Oncol. 2012 Jun;19(6):1966-72. doi: 10.1245/s10434-011-2153-x. Epub 2011 Nov 29.
Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) are measures of metabolic activity of tumors determined by fluorine-18 fluorodeoxyglucose ([(18)F]FDG) uptake on PET/CT images. The purpose of this study was to investigate the relationship between functional tumor parameters (MTV and TLG) and clinical outcomes in patients with epithelial ovarian cancer (EOC).
Fifty-five patients with EOC who had undergone [(18)F]FDG PET/CT before surgical staging were included in this retrospectively study. For each patient, we determined the highest (SUV(max) and SUV(avg)), the cumulative TLG, and the sum of all MTV, and compared their predictive value of recurrence and the effects of pretreatment functional tumor activity on progression-free interval (PFI).
The median duration of PFI was 11 (range 3-43) months, and 20 patients (36.4%) experienced recurrence. Poor outcome was associated with higher values for both the MTV (P = 0.022, hazard ratio 5.571, 95% confidence interval 1.279-24.272) and the TLG (P = 0.037, hazard ratio 2.967, 95% confidence interval 1.065-8.265). The Kaplan-Meier survival graphs showed a significant difference in PFI between the groups categorized by MTV and TLG, respectively (P = 0.01 for MTV, P = 0.0287 for TLG, log rank test).
Pretreatment metabolic parameters such as MTV and TLG showed statistically significant association with recurrence in patients with EOC. These values can be useful quantitative criteria for disease prognostication in patients with EOC before treatment.
代谢肿瘤体积（MTV）和总肿瘤糖酵解（TLG）是通过氟-18 氟代脱氧葡萄糖 ([(18)F]FDG) 在 PET/CT 图像上摄取来衡量肿瘤代谢活性的指标。本研究旨在探讨上皮性卵巢癌（EOC）患者功能肿瘤参数（MTV 和 TLG）与临床结局之间的关系。
本回顾性研究纳入了 55 例在手术分期前接受 [(18)F]FDG PET/CT 的 EOC 患者。对于每位患者，我们确定了最高（SUV(max) 和 SUV(avg)）、累积 TLG 和所有 MTV 的总和，并比较了它们对复发的预测价值以及治疗前功能肿瘤活性对无进展生存期（PFI）的影响。
PFI 的中位时间为 11 个月（范围 3-43 个月），20 例患者（36.4%）复发。不良结局与 MTV（P = 0.022，风险比 5.571，95%置信区间 1.279-24.272）和 TLG（P = 0.037，风险比 2.967，95%置信区间 1.065-8.265）值均较高有关。Kaplan-Meier 生存曲线显示，根据 MTV 和 TLG 分类的 PFI 之间存在显著差异（MTV 组 P = 0.01，TLG 组 P = 0.0287，对数秩检验）。
治疗前代谢参数如 MTV 和 TLG 与 EOC 患者的复发具有统计学显著相关性。这些值可作为治疗前 EOC 患者疾病预后的有用定量标准。
