Travaglio Morales Daniela, Huerga Cabrerizo Carlos, Losantos García Itsaso, Coronado Poggio Mónica, Cordero García José Manuel, Llobet Elena López, Monachello Araujo Domenico, Rizkallal Monzón Sebastián, Domínguez Gadea Luis
Nuclear Medicine Department, La Paz University Hospital, 28046 Madrid, Spain.
Nuclear Medicine Department, Halle University Hospital, 06120 Halle, Germany.
Diagnostics (Basel). 2023 Nov 7;13(22):3394. doi: 10.3390/diagnostics13223394.
High-grade serous ovarian cancer (HGSOC) is an aggressive disease with different clinical outcomes and poor prognosis. This could be due to tumor heterogeneity. The 18F-FDG PET radiomic parameters permit addressing tumor heterogeneity. Nevertheless, this has been not well studied in ovarian cancer. The aim of our work was to assess the prognostic value of pretreatment 18F-FDG PET radiomic features in patients with HGSOC. A review of 36 patients diagnosed with advanced HGSOC between 2016 and 2020 in our center was performed. Radiomic features were obtained from pretreatment F-FDGPET. Disease-free survival (DFS) and overall survival (OS) were calculated. Optimal cutoff values with receiver operating characteristic curve/median values were used. A correlation between radiomic features and DFS/OS was made. The mean DFS was 19.6 months and OS was 37.1 months. Total Lesion Glycolysis (TLG), GLSZM_ Zone Size Non-Uniformity (GLSZM_ZSNU), and GLRLM_Run Length Non-Uniformity (GLRLM_RLNU) were significantly associated with DFS. The survival-curves analysis showed a significant difference of DSF in patients with GLRLM_RLNU > 7388.3 versus patients with lower values (19.7 months vs. 31.7 months, = 0.035), maintaining signification in the multivariate analysis ( 0.048). Moreover, Intensity-based Kurtosis was associated with OS ( = 0.027). Pretreatment F-FDG PET radiomic features GLRLM_RLNU, GLSZM_ZSNU, and Kurtosis may have prognostic value in patients with advanced HGSOC.
高级别浆液性卵巢癌（HGSOC）是一种侵袭性疾病，具有不同的临床结局且预后较差。这可能归因于肿瘤异质性。18F-FDG PET影像组学参数有助于解决肿瘤异质性问题。然而，这在卵巢癌中尚未得到充分研究。我们研究的目的是评估治疗前18F-FDG PET影像组学特征对HGSOC患者的预后价值。我们对2016年至2020年在我们中心诊断为晚期HGSOC的36例患者进行了回顾性研究。影像组学特征来自治疗前的F-FDG PET。计算无病生存期（DFS）和总生存期（OS）。使用受试者工作特征曲线/中位数的最佳截断值。分析影像组学特征与DFS/OS之间的相关性。平均DFS为19.6个月，OS为37.1个月。总病变糖酵解（TLG）、灰度共生矩阵区域大小非均匀性（GLSZM_ZSNU）和灰度游程长度矩阵游程长度非均匀性（GLRLM_RLNU）与DFS显著相关。生存曲线分析显示，GLRLM_RLNU>7388.3的患者与较低值患者的DSF存在显著差异（19.7个月对31.7个月，P = 0.035），在多变量分析中保持显著性（P = 0.048）。此外，基于强度的峰度与OS相关（P = 0.027）。治疗前F-FDG PET影像组学特征GLRLM_RLNU、GLSZM_ZSNU和峰度可能对晚期HGSOC患者具有预后价值。
