Imperial College London, St. Mary's Campus, London, UK.
Adv Exp Med Biol. 2011;719:81-103. doi: 10.1007/978-1-4614-0204-6_8.
The recent H1N1 pandemic that emerged in 2009 has illustrated how swiftly a new influenza virus can circulate the globe. Here we explain the origins of the 2009 pandemic virus, and other twentieth century pandemics. We also consider the impact of the 2009 pandemic in the human population and the use of vaccines and antiviral drugs. Thankfully this outbreak was much less severe than that associated with Spanish flu in 1918. We describe the viral factors that affect virulence of influenza and speculate on the future course of this virus in humans and animals.
2009 年爆发的最近一次 H1N1 大流行表明，新的流感病毒可以在全球范围内迅速传播。在这里，我们解释了 2009 年大流行病毒的起源以及其他 20 世纪的大流行。我们还考虑了 2009 年大流行对人类的影响，以及疫苗和抗病毒药物的使用。谢天谢地，这次疫情的严重程度远低于 1918 年西班牙流感。我们描述了影响流感毒力的病毒因素，并推测了这种病毒在人类和动物中的未来发展。
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