Department of Pediatric Pneumology and Immunology, Helmut-Ruska-Haus, Charité Universitätsmedizin Berlin, Berlin, Germany.
Clin Infect Dis. 2010 Dec 1;51(11):e90-4. doi: 10.1086/657121. Epub 2010 Nov 1.
Patients infected with human immunodeficiency virus type 1 (HIV-1) are considered to be at increased risk for 2009 H1N1 influenza-related complications. We performed an observational study after an outbreak of 2009 H1N1 influenza virus infection among a group of 15 HIV-1-infected school-aged children in Germany in October 2009. Clinical course, kinetics of viral shedding, and antibody response among children with CD4 cell counts >350 cells/μL and 2009 H1N1 influenza virus coinfection did not appear to differ from that among healthy children. Oseltamivir shortened the duration of viral shedding.
感染人类免疫缺陷病毒 1 型 (HIV-1) 的患者被认为患 2009 年甲型 H1N1 流感相关并发症的风险增加。我们在 2009 年 10 月德国一组 15 名感染 HIV-1 的学龄儿童中暴发 2009 年甲型 H1N1 流感病毒感染后进行了一项观察性研究。CD4 细胞计数 >350 个/μL 的儿童和 2009 年甲型 H1N1 流感病毒合并感染的儿童的临床过程、病毒脱落动力学和抗体反应似乎与健康儿童没有差异。奥司他韦缩短了病毒脱落的持续时间。