异烟肼免疫调节特性的研究。II. 异烟肼对白细胞介素2产生及白细胞介素2受体表达的影响。
Studies on immunomodulatory properties of isoniazid. II. Effect of isoniazid on interleukin 2 production and interleukin 2-receptor expression.
作者信息
Kucharz E J, Sierakowski S J
机构信息
Department of Medicine, Medical College of Wisconsin, Milwaukee.
出版信息
J Hyg Epidemiol Microbiol Immunol. 1990;34(2):207-11.
The effect of isoniazid on interleukin 2 production and interleukin 2-receptor expression by phytohemagglutinin-stimulated human T cells was investigated. High concentrations of the drug decreased interleukin 2 production while low doses (10(-5)-10(-6) M) produced a slight increase in interleukin 2 production. Isoniazid did not affect the expression of interleukin 2-receptors on the surface of T cells, except a slight decrease in cells exposed to high levels of the drug.
研究了异烟肼对植物血凝素刺激的人T细胞产生白细胞介素2及白细胞介素2受体表达的影响。高浓度药物可降低白细胞介素2的产生，而低剂量（10⁻⁵ - 10⁻⁶ M）则使白细胞介素2的产生略有增加。异烟肼不影响T细胞表面白细胞介素2受体的表达，但在接触高剂量药物的细胞中会有轻微下降。
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