Kucharz E J, Sierakowski S J
Department of Medicine, Medical College of Wisconsin, Milwaukee.
J Hyg Epidemiol Microbiol Immunol. 1988;32(2):147-52.
Immunomodulatory properties of copper were investigated. Human T cells, isolated from blood of healthy donors, were stimulated with phytohemagglutinin and cultured in vitro. It was found that copper sulphate depressed T cell proliferation when added in concentration of 10(-3) M. A slight increase in the T cell proliferation was shown in presence of 10(-5) M of copper ion while 10(-7)-10(-9) M had no effect on proliferation. Production of interleukin 2 by human T cells was depressed by all investigated doses of copper. The obtained results suggest the direct toxicity of copper on T cell activation.
对铜的免疫调节特性进行了研究。从健康供体血液中分离出的人T细胞，用植物血凝素刺激并在体外培养。结果发现，当以10(-3) M的浓度添加硫酸铜时，会抑制T细胞增殖。当存在10(-5) M的铜离子时，T细胞增殖略有增加，而10(-7)-10(-9) M对增殖没有影响。所有研究剂量的铜都会抑制人T细胞白细胞介素2的产生。所得结果表明铜对T细胞活化具有直接毒性。
