Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Head Neck. 2012 Jun;34(6):877-85. doi: 10.1002/hed.21830. Epub 2011 Aug 24.
The present study uses population-based data from the Surveillance, Epidemiology, and End Results (SEER) database to evaluate the behavior of sinonasal tumors.
Data for all sinonasal malignancies reported between 1973 and 2006 (n = 6739) were extracted from the database. Time-dependent trends in incidence and survival were analyzed by linear regression.
The overall incidence of sinonasal cancer was 0.556 cases per 100,000 population per year with a male:female ratio of 1.8:1. The most common histologies were squamous cell carcinoma (51.6%) and adenocarcinoma (12.6%), whereas the most common primary sites were the nasal cavity (43.9%) and maxillary sinus (35.9%). The incidence of sinonasal cancer remained relatively stable during the study period. No significant changes in overall relative survival were noted. The best relative survival was noted in patients treated with surgery or a combination of surgery and radiotherapy.
The prognosis of patients with sinonasal cancer is generally poor, and has not changed substantially over the last 3 decades.
本研究利用基于人群的监测、流行病学和最终结果（SEER）数据库的数据来评估鼻旁窦肿瘤的行为。
从数据库中提取 1973 年至 2006 年间报告的所有鼻旁窦恶性肿瘤的数据。通过线性回归分析发病率和生存率的时间依赖性趋势。
鼻旁窦癌的总体发病率为每年每 100,000 人口 0.556 例，男女比例为 1.8:1。最常见的组织学类型是鳞状细胞癌（51.6%）和腺癌（12.6%），而最常见的原发部位是鼻腔（43.9%）和上颌窦（35.9%）。在研究期间，鼻旁窦癌的发病率相对稳定。总相对生存率没有显著变化。接受手术或手术联合放疗治疗的患者的相对生存率最好。
鼻旁窦癌患者的预后一般较差，在过去 30 年中没有发生实质性变化。
