Allahverdi Mahmoud, Sarkhosh Mina, Aghili Mahdi, Jaberi Ramin, Adelnia Akbar, Geraily Ghazale
Department of Radiation Oncology, Cancer Research Center, Tehran University of Medical Science, Tehran, Iran.
Radiat Prot Dosimetry. 2012 Jul;150(3):312-5. doi: 10.1093/rpd/ncr415. Epub 2011 Nov 28.
The aim of this study was to assess the actual dose delivered to the rectum and compare it with the treatment planning system (TPS) reports. In this study, the dose delivered to the rectum was measured by semiconductor diode detectors (PTW, Germany). The factors that influence diode response were investigated as well. Calibration factors of diodes were measured weekly to investigate the effect of time interval on the accuracy of calibration. Then 40 applications of patients with cervix carcinoma were evaluated. Rectum dose was measured by means of rectal dosemeter and compared with the TPS-calculated dose. In this research, the differences between the measured and the calculated dose were investigated. The mean difference between the TPS-calculated dose and the measured dose was 6.5% (range: -22 to +39) for rectum. The TPS-calculated maximum dose was typically higher than the measured maximum dose. The study showed that the main reason for the difference was due to the movements of the patient and applicator shift in the elapsed time between the imaging and treatment stage. It is recommended that in vivo dosimetry should be performed in addition to treatment planning computation. In vivo dosimetry is a reliable solution to compare the planned and actual dose delivered to organs at risk.
本研究的目的是评估直肠实际接受的剂量,并将其与治疗计划系统(TPS)报告进行比较。在本研究中,直肠接受的剂量通过半导体二极管探测器(德国PTW)进行测量。同时还研究了影响二极管响应的因素。每周测量二极管的校准因子,以研究时间间隔对校准准确性的影响。然后对40例宫颈癌患者的治疗情况进行了评估。通过直肠剂量仪测量直肠剂量,并与TPS计算的剂量进行比较。在本研究中,对测量剂量与计算剂量之间的差异进行了研究。直肠的TPS计算剂量与测量剂量之间的平均差异为6.5%(范围:-22%至+39%)。TPS计算的最大剂量通常高于测量的最大剂量。研究表明,差异的主要原因是患者的移动以及在成像和治疗阶段之间的时间间隔内施源器的移位。建议除治疗计划计算外,还应进行体内剂量测定。体内剂量测定是比较计划给予和实际给予危及器官剂量的可靠方法。