Smith K B, Lunn S F, Fraser H M
MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh.
J Endocrinol. 1990 Sep;126(3):489-95. doi: 10.1677/joe.0.1260489.
Changes in plasma concentrations of immunoreactive inhibin in the reproductively cyclic, pregnant and ovariectomized female marmoset monkey (Callithrix jacchus) were measured with a heterologous radioimmunoassay. The pattern of inhibin secretion in five marmosets studied individually during four consecutive cycles was shown to resemble that of progesterone. In these animals, data were pooled according to stage of cycle on the basis of plasma progesterone concentrations. Mean values for inhibin were 5465 and 4972 U/l during the early and late follicular phase. Concentrations rose during the luteal phase to 8431, 12,246 and 12,557 U/l for the early, mid- and late luteal phase respectively. The hormonal profile of inhibin during the normal cycle is similar in both marmoset and stumptailed macaque; however, the marmoset has a 28-fold greater level of inhibin during the luteal phase. In six marmosets in which pregnancy occurred, inhibin concentrations showed no decline at the end of the conceptual cycle and remained increased with respect to the follicular phase throughout the subsequent gestation. Inhibin levels were non-detectable (less than 1000 U/l) in ovariectomized and acyclic marmosets. These results suggest that the corpus luteum is the major source of inhibin in this New World monkey, in common with man and the Old World primates.
采用异源放射免疫分析法测定了处于生殖周期、怀孕和卵巢切除状态的雌性狨猴（Callithrix jacchus）血浆中免疫反应性抑制素的浓度变化。对五只狨猴在连续四个周期中分别进行研究，结果显示抑制素的分泌模式与孕酮相似。在这些动物中，根据血浆孕酮浓度按周期阶段汇总数据。卵泡早期和晚期抑制素的平均值分别为5465和4972 U/l。黄体期浓度上升，黄体早期、中期和晚期分别升至8431、12246和12557 U/l。正常周期中抑制素的激素谱在狨猴和短尾猕猴中相似；然而，狨猴在黄体期的抑制素水平要高出28倍。在六只怀孕的狨猴中，抑制素浓度在妊娠周期结束时没有下降，并且在随后的整个妊娠期相对于卵泡期一直保持升高。在卵巢切除和无周期的狨猴中未检测到抑制素水平（低于1000 U/l）。这些结果表明，与人类和旧世界灵长类动物一样，黄体是这种新大陆猴中抑制素的主要来源。
