Mikkers Harald M M, Hoeben Rob C
Leids Universitair Medisch Centrum, afd. Moleculaire Celbiologie, Leiden, the Netherlands.
Ned Tijdschr Geneeskd. 2011;155(47):A3565.
Stem cells are being used more frequently for research and experimental therapy, but as yet the clinical applications of stem cells are limited. Pluripotent stem cells, with embryonic stem cells as the most well know example, can differentiate into each cell type; in contrast, tissue specific stem cells can only form one or more cell types within one type of tissue. It has been possible for some time to reprogram different types of somatic cells into pluripotent stem cells. Such stem cells are termed induced pluripotent stem cells (iPS cells). iPS cells can also be created from cells of patients with genetic conditions. Research into mechanisms of pathology and new medicines can be carried out with these against a specific genetic background. Clinical application of such iPS cells is not to be expected in the short term. Facilities are being established in different Dutch academic centres to create iPS cells for scientific research.
none declared.
干细胞正越来越频繁地用于研究和实验性治疗，但目前干细胞的临床应用仍然有限。多能干细胞，以胚胎干细胞最为人所知，能够分化为每种细胞类型；相比之下，组织特异性干细胞只能在一种组织内形成一种或多种细胞类型。一段时间以来，已经能够将不同类型的体细胞重编程为多能干细胞。这类干细胞被称为诱导多能干细胞（iPS细胞）。iPS细胞也可以从患有遗传疾病的患者细胞中产生。利用这些细胞可以针对特定的遗传背景开展病理学机制和新药研究。短期内这类iPS细胞的临床应用尚不可期。荷兰不同的学术中心正在建立相关设施，以制备用于科研的iPS细胞。
未声明。
