Mycoplus Co., Ltd., Anyang 431–080, Korea.
Biol Pharm Bull. 2011;34(12):1881-4. doi: 10.1248/bpb.34.1881.
Ovalicin, a secondary metabolite produced by an entomopathogenic fungus Metarhizium anisopliae var. anisopliae, is currently used as an efficient biological control agent against various agricultural insect pests, but not so many biological activities have been investigated. To assess whether ovalicin has potential in ameliorating atopic dermatitis-related symptoms in mice, we first sensitized skin in the dorsal neck of Balb/c mice using compound 48/80, and scrutinized whether the compound affected the atopic dermatitis-related symptoms. The results revealed that ovalicin significantly reduces scratching behavior in a concentration-dependent fashion. Moreover, the treatment inhibits the levels of the degranulation of mast cells by 65%, and levels of histamine release by 51% at a concentration of 10 µg/ml. Together, the present data strongly suggest that ovalicin elicits potential anti-atopic activities in mice.
卵形菌素是一种由昆虫病原真菌金龟子绿僵菌变种金龟子绿僵菌产生的次生代谢产物，目前被用作防治各种农业害虫的高效生物防治剂，但对其生物活性的研究还不多。为了评估卵形菌素是否具有改善过敏性皮炎相关症状的潜力，我们首先使用化合物 48/80 致敏 Balb/c 小鼠的颈背部皮肤，并仔细观察该化合物是否影响过敏性皮炎相关症状。结果表明，卵形菌素以浓度依赖性方式显著减少搔抓行为。此外，在 10 µg/ml 浓度下，卵形菌素可使脱颗粒的肥大细胞水平降低 65%，组胺释放水平降低 51%。综上所述，本研究数据强烈表明卵形菌素在小鼠中具有潜在的抗过敏性作用。
