Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California, USA.
Fertil Steril. 2012 Jan;97(1):238-43. doi: 10.1016/j.fertnstert.2011.10.031. Epub 2011 Nov 30.
To identify markers of ovarian age that best match the pattern of oocyte loss seen in histology specimens.
Cross-sectional study.
University.
PATIENT(S): Caucasian women (n = 252) aged 25-45 years.
INTERVENTION(S): none.
MAIN OUTCOME MEASURE(S): The relationship between antral follicle count (AFC), antimüllerian hormone (AMH), inhibin B, FSH, and E(2) with age was estimated using the power model, which previously has been shown to most accurately describe oocyte loss in histologic specimens. The power model was fit to each marker and used to compare the rates of change at ages 30 and 40 with the histologic pattern. Among those markers following the pattern, R(2) was used to compare the degree of relationship with age.
RESULT(S): Both AMH levels and AFC exhibited significant progressive declines with age. The average rates of loss per year for AFC and AMH were, respectively, -0.57 and -1.09 at age 30, and -1.33 and -3.06 at age 40. FSH, inhibin B, and E(2) did not exhibit progressive rates of change. The R(2) for AFC was 27.3% and for AMH was 22.7%.
CONCLUSION(S): Only AFC and AMH follow the pattern of oocyte loss observed histologically. Although AMH may be more cost-effective, AFC is a slightly more accurate noninvasive measure for ovarian aging.
确定与组织学标本中所见卵母细胞丢失模式最匹配的卵巢年龄标志物。
横断面研究。
大学。
25-45 岁的白种女性（n=252）。
无。
使用幂模型评估卵泡计数（AFC）、抗苗勒管激素（AMH）、抑制素 B、FSH 和 E2 与年龄的关系，该模型先前已被证明最能准确描述组织学标本中的卵母细胞丢失。幂模型拟合到每个标志物上，并用于比较 30 岁和 40 岁时的变化率与组织学模式。在遵循该模式的标志物中，R2 用于比较与年龄的关系程度。
AMH 水平和 AFC 均随年龄呈显著下降趋势。AFC 和 AMH 的平均年损失率分别为 30 岁时-0.57 和-1.09，40 岁时-1.33 和-3.06。FSH、抑制素 B 和 E2 未显示出渐进性变化率。AFC 的 R2 为 27.3%，AMH 的 R2 为 22.7%。
只有 AFC 和 AMH 符合组织学观察到的卵母细胞丢失模式。虽然 AMH 可能更具成本效益，但 AFC 是一种更准确的卵巢老化的非侵入性测量方法。
