Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Sciences: University of California, San Francisco, California 94115, USA.
Fertil Steril. 2011 May;95(6):1950-4, 1954.e1. doi: 10.1016/j.fertnstert.2011.01.151. Epub 2011 Mar 3.
To determine whether infertile women have lower antral follicle counts (AFC) than age-matched normal women.
Case-control.
Academic center.
PATIENT(S): A total of 881 infertile women and 771 women from the community.
INTERVENTION(S): Antral follicle count and basal hormone measurements.
MAIN OUTCOME MEASURE(S): Median AFCs and FSH levels were compared between the two groups within 5-year age strata by using the median test. A subanalysis was performed by identifying women in the control group with a history of attempting conception without success (subfertile group) and with a spontaneous conception in fewer than 12 months resulting in a live birth (fertile group). Age-specific AFC percentiles were calculated and compared within strata determined by age at the time of attempted conception.
RESULT(S): AFCs were significantly lower in infertile women than in control women across age groups up to 40 years of age. Average FSH levels were significantly higher in the younger-age infertile group versus the community. AFC percentiles differ significantly between fertile and subfertile women within the community up to 40 years of age.
CONCLUSION(S): Decreased AFC in infertile women suggests that factors affecting the size of the remaining follicle pool in younger women also affect oocyte quality and the likelihood of conception.
确定不孕女性的窦卵泡计数（AFC）是否低于年龄匹配的正常女性。
病例对照研究。
学术中心。
共 881 名不孕女性和 771 名来自社区的女性。
窦卵泡计数和基础激素测量。
通过中位数检验比较两组在 5 年内年龄分层内的中位数 AFC 和 FSH 水平。通过识别对照组中具有尝试受孕但未成功的历史（亚生育组）和在 12 个月内自然受孕导致活产（生育组）的女性进行亚分析。按尝试受孕时的年龄分层计算和比较年龄特异性 AFC 百分位数。
在 40 岁以下的年龄组中，不孕女性的 AFC 明显低于对照组女性。在年轻的不孕组中，平均 FSH 水平明显高于社区。在 40 岁以下的社区中，生育和亚生育女性之间的 AFC 百分位数差异显著。
不孕女性的 AFC 减少表明，影响年轻女性剩余卵泡池大小的因素也会影响卵母细胞质量和受孕的可能性。
