早期亨廷顿舞蹈病患者无胃排空受损的证据。
No evidence of impaired gastric emptying in early Huntington's Disease.
作者信息
Saft Carsten, Andrich Jürgen, Fälker Marc, Gauda Sarah, Küchler Sina, Woitalla Dirk, Goetze Oliver
机构信息
Department of Neurology, Huntington-Center NRW, Ruhr-University, St. Josef-Hospital, Bochum, Germany; Department of Medicine 1, St. Josef-Hospital, University of Bochum, Germany; Department of Neurology, Huntington-Center NRW, Ruhr-University, St. Josef Hospital, Bochum, Germany; Department of Neurology, Huntington Center- NRW, Ruhr-University, St. Joseph Hospital, Bochum, Germany and Division of Gastroenterology and Hepatology; University Hospital Zurich; Zurich, Switzerland.
出版信息
PLoS Curr. 2011 Oct 25;3:RRN1284. doi: 10.1371/currents.RRN1284.
BACKGROUND
Several factors, such as dysphagia, an increased motor activity, increased metabolic rate and a hypermetabolic state have been discussed as contributing to weight loss even at the early stages of Huntington's Disease (HD). Aim of this pilot study was to investigate gastric emptying as a possible reason for weight loss in HD.
METHODS
11 HD participants at early stages of the disease and matched controls were investigated by using the well-established and non-invasive 13C-octanoate breath test. The "Gastroparesis Cardinal Symptom Index" and the "Short-Form Leeds Dyspepsia Questionnaire" were used for clinical evaluation of gastroparesis or dyspepsia.
RESULTS
When compared to standard values given in literature and controls all HD patients had normal breath test results. There was no evidence of gastroparesis or dyspepsia. There was a correlation of breath test results with the cognitive and functional performance of HD participants.
CONCLUSION
According to our data, there is no evidence of impaired gastric emptying in early HD. We can not exclude that gastric emptying contributes to weight loss at more advanced stages of the disease.
背景
吞咽困难、运动活动增加、代谢率提高和高代谢状态等多种因素已被讨论为即使在亨廷顿舞蹈病（HD）早期也导致体重减轻的原因。这项初步研究的目的是调查胃排空作为HD体重减轻的一个可能原因。
方法
通过使用成熟的非侵入性13C-辛酸呼气试验对11名处于疾病早期的HD参与者和匹配的对照组进行了调查。“胃轻瘫主要症状指数”和“利兹消化不良简易问卷”用于胃轻瘫或消化不良的临床评估。
结果
与文献中给出的标准值和对照组相比，所有HD患者的呼气试验结果均正常。没有胃轻瘫或消化不良的证据。呼气试验结果与HD参与者的认知和功能表现存在相关性。
结论
根据我们的数据，没有证据表明早期HD患者胃排空受损。我们不能排除在疾病更晚期胃排空导致体重减轻的可能性。
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