犬 ASCT1 和 ASCT2 是犬 RD-114 病毒的功能性受体。
Canine ASCT1 and ASCT2 are functional receptors for RD-114 virus in dogs.
机构信息
Graduate School of Human and Environmental Studies, Kyoto University, Yoshida-Nihonmatsucho, Sakyo-ku, Kyoto 606-8501, Japan.
Laboratory of Primate Model, Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan.
出版信息
J Gen Virol. 2012 Mar;93(Pt 3):603-607. doi: 10.1099/vir.0.036228-0. Epub 2011 Nov 30.
All domestic cats carry an infectious endogenous retrovirus termed RD-114 virus. Recently, we and others found that several live-attenuated vaccines for dogs were contaminated with infectious RD-114 virus. In this study, we confirmed that the RD-114 virus efficiently infected and proliferated well in canine primary kidney cells, as well as three tested canine cell lines. Further, we identified canine ASCT1 and ASCT2, sodium-dependent neutral amino acid transporters, as RD-114 virus receptors. Canine ASCT2 also acts as a functional receptor for simian retrovirus 2, a pathogenic retrovirus that induces immunodeficiency in rhesus macaques. Identification of the canine receptor for RD-114 virus will help in evaluating the risk from vaccines contaminated by the virus.
所有家猫都携带一种称为 RD-114 病毒的传染性内源性逆转录病毒。最近，我们和其他人发现，几种用于狗的减毒活疫苗被传染性 RD-114 病毒污染。在这项研究中，我们证实 RD-114 病毒能够有效地感染和在犬原代肾细胞以及三种测试的犬细胞系中很好地增殖。此外，我们鉴定了犬 ASCT1 和 ASCT2，即钠依赖性中性氨基酸转运体，为 RD-114 病毒的受体。犬 ASCT2 也是猴免疫缺陷病毒 2 的功能性受体，猴免疫缺陷病毒 2 是一种致病性逆转录病毒，可导致猕猴免疫缺陷。鉴定 RD-114 病毒的犬受体将有助于评估受病毒污染的疫苗的风险。
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