Bouve College of Health Sciences, Northeastern University, Boston, MA, USA.
Nutr Rev. 2011 Dec;69(12):720-9. doi: 10.1111/j.1753-4887.2011.00423.x.
Glucose is transported across the cell membrane by two different types of glucose transporters: glucose-facilitated transporters and sodium-dependent glucose transport (SGLT) proteins. Regulation of SGLT activity (namely, inhibition of SGLT1 and SGLT2 activity and stimulation of SGLT3 activity) represents a potential means of managing hyperglycemia and diabetes, thus preventing complications of diabetes. The purpose of the present review is to discuss the role of SGLT proteins in the pathophysiology of diabetes and to describe the mechanisms by which these transporters may be used for glycemic control and the treatment of diabetes. The regulatory processes involved in SGLT-mediated glucose uptake are also described briefly. This information provides new insight into the complementary mechanisms involved in the regulation of SGLT-mediated glucose transport as well as a basis for further investigation.
葡萄糖易化转运蛋白和钠依赖性葡萄糖转运（SGLT）蛋白。SGLT 活性的调节（即，抑制 SGLT1 和 SGLT2 活性和刺激 SGLT3 活性）代表了一种管理高血糖和糖尿病的潜在手段，从而预防糖尿病并发症。本综述的目的是讨论 SGLT 蛋白在糖尿病病理生理学中的作用，并描述这些转运体可能用于血糖控制和糖尿病治疗的机制。还简要描述了涉及 SGLT 介导的葡萄糖摄取的调节过程。这些信息为 SGLT 介导的葡萄糖转运的调节所涉及的互补机制提供了新的见解，并为进一步的研究提供了基础。
