Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, People's Republic of China.
Nano Lett. 2012 Jan 11;12(1):61-7. doi: 10.1021/nl202949y. Epub 2011 Dec 1.
Nanorattles consisting of hydrophilic, rare-earth-doped NaYF(4) shells each containing a loose magnetic nanoparticle were fabricated through an ion-exchange process. The inner magnetic Fe(3)O(4) nanoparticles are coated with a SiO(2) layer to avoid iron leaching in acidic biological environments. This multifunctional mesoporous nanostructure with both upconversion luminescent and magnetic properties has excellent water dispersibility and a high drug-loading capacity. The material emits visible luminescence upon NIR excitation and can be directed by an external magnetic field to a specific target, making it an attractive system for a variety of biological applications. Measurements on cells incubated with the nanorattles show them to have low cytotoxicity and excellent cell imaging properties. In vivo experiments yield highly encouraging tumor shrinkage with the antitumor drug doxorubicin (DOX) and significantly enhanced tumor targeting in the presence of an applied magnetic field.
通过离子交换过程制备了由亲水性、掺杂稀土的 NaYF(4) 壳组成的纳米摇铃，每个壳中都含有一个松散的磁性纳米颗粒。内层的磁性 Fe(3)O(4)纳米颗粒涂有一层 SiO(2) 层，以避免在酸性生物环境中铁的浸出。这种具有上转换发光和磁性的多功能介孔纳米结构具有优异的水分散性和高载药能力。该材料在近红外激发下发出可见光，并且可以在外磁场的作用下被引导到特定的目标，使其成为各种生物应用的有吸引力的系统。对与纳米摇铃孵育的细胞进行的测量表明，它们具有低细胞毒性和优异的细胞成像特性。体内实验显示，阿霉素 (DOX) 的抗肿瘤药物和在施加磁场的情况下肿瘤靶向性都得到了显著增强，从而使肿瘤显著缩小。
