miRNA 加工与人类癌症：DICER1 必不可少。
miRNA processing and human cancer: DICER1 cuts the mustard.
机构信息
Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montreal, Quebec H2W 1S6, Canada.
出版信息
Sci Transl Med. 2011 Nov 30;3(111):111ps46. doi: 10.1126/scitranslmed.3002493.
Numerous studies have implicated microRNAs (miRNAs) in cancer initiation and progression. In contrast, only recently has attention been focused on the pathway that generates these regulatory molecules. The identification of neoplasia-associated germline mutations in DICER1 has focused translational research on components of the miRNA processing pathway. Deciphering of the many links between miRNA processing perturbations and cancer will likely provide insights into mechanisms of cancer control.
大量研究表明 microRNAs（miRNAs）在癌症的发生和发展中起作用。相反，直到最近人们才开始关注产生这些调节分子的途径。DICER1 中与肿瘤相关的种系突变的鉴定使人们将转化研究的重点放在 miRNA 加工途径的组成部分上。miRNA 加工扰动与癌症之间的许多联系的破译，可能会为癌症控制的机制提供新的见解。
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