泰国 11-13(+6) 周胎儿鼻骨长度正常值参考值。

A Thai reference for normal fetal nasal bone length at 11-13(+6) weeks gestation.

机构信息

Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.

出版信息

Gynecol Obstet Invest. 2012;73(3):211-6. doi: 10.1159/000333238. Epub 2011 Dec 1.

DOI:10.1159/000333238

PMID:22133723

Abstract

AIM

The purpose of this study was to establish a Thai reference for normal fetal nasal bone length (NBL) at 11-13(+6) weeks gestation.

METHODS

The fetal nasal bone was measured by sonography in pregnant women at 11-13(+6) weeks gestation. All neonates who showed normal karyotypes were examined after delivery to confirm the absence of congenital abnormalities.

RESULTS

A total of 255 pregnant women were recruited. Forty-seven pregnant women were excluded from the analysis because of technically unsatisfactory examination or absent nasal bone and chromosomal abnormalities. The mean ± SD of NBL was 1.79 ± 0.33 mm and increased significantly with crown-rump length (CRL) and gestational age (p < 0.001). The best-fit equation for NBL in euploid fetuses in relation to CRL was: NBL (mm) = (0.030 × CRL (mm)) - 0.016.

CONCLUSION

NBL in Thai fetuses at 11-13(+6) weeks was found to be on average shorter than that in Caucasian, African-American and Chinese populations, but similar to those reported in Korean and Latin-American populations.

摘要

目的

本研究旨在建立 11-13（+6）周妊娠胎儿鼻骨长度（NBL）的泰国参考值。

方法

在 11-13（+6）周妊娠的孕妇中通过超声测量胎儿鼻骨。所有分娩后显示正常核型的新生儿均接受检查以确认无先天性异常。

结果

共纳入 255 名孕妇。47 名孕妇因检查技术不满意或鼻骨和染色体异常而被排除在分析之外。NBL 的平均值±SD 为 1.79±0.33mm，与头臀长（CRL）和胎龄呈显著正相关（p<0.001）。在整倍体胎儿中，NBL 与 CRL 的最佳拟合方程为：NBL（mm）=（0.030×CRL（mm））-0.016。