Cansu A, Ozgur H, Guven S, Dinc G, Dinc H
Clin Exp Obstet Gynecol. 2014;41(5):556-60.
To develop a nomogram for estimating nasal bone length (NBL) at 11(+0) - 13(+6) weeks of gestation in 554 consecutive cases and to determine the value of NBL measurement in screening for chromosomal abnormalities.
NBL and crown-rump length (CRL) were examined in 554 fetuses at 11(+0) - 13(+6) weeks' gestation. A nomogram for NBL was developed with data from 479 healthy fetuses in which fetal profile examination was possible. Reference values, including percentiles, weie calculated for each gestational age.
A linear correlation was noted between CRL and NBL in healthy fetuses at 11(+0) - 11(+6), 12(+0) - 12(+6) and 13(+0) - 13(+6) weeks of gestation. Mean NBL was 2.18 +/- 0.53 mm, 2.46 +/- 0.45 mm, and 2.91 +/- 0.55 mm in healthy fetuses, for these time frames, respectively. NBL increased significantly with CRL from respective means of 2.26 +/- 0.43, 2.60 +/- 0.48, 2.77 +/- 0.43, and 3.16 +/- 0.52 mm at 45 - 54.9, 55 - 64.9, 65 +/- 74.9, and 75 - 84 mm.
The authors developed a NBL nomogram with data from normal, healthy Turkish fetuses at 11(+0) - 13(+6) weeks of gestation. These reference ranges may prove useful in prenatal screening and diagnosis of syndromes known to be associated with nasal hypoplasia.
为554例连续病例建立一个用于估算妊娠11（+0）至13（+6）周时鼻骨长度（NBL）的列线图，并确定NBL测量在筛查染色体异常中的价值。
对554例妊娠11（+0）至13（+6）周的胎儿进行NBL和头臀长（CRL）检查。利用479例可进行胎儿轮廓检查的健康胎儿的数据建立了NBL列线图。计算了每个孕周的参考值，包括百分位数。
在妊娠11（+0）至11（+6）周、12（+0）至12（+6）周和13（+0）至13（+6）周的健康胎儿中，CRL与NBL之间存在线性相关性。在这些时间段内，健康胎儿的平均NBL分别为2.18±0.53mm、2.46±0.45mm和2.91±0.55mm。随着CRL从45至54.9、55至64.9、65至74.9和75至84mm时各自的平均值2.26±0.43、2.60±0.48、2.77±0.43和3.16±0.52mm显著增加，NBL也显著增加。
作者利用妊娠11（+0）至13（+6）周的正常、健康土耳其胎儿的数据建立了NBL列线图。这些参考范围可能有助于产前筛查和诊断已知与鼻发育不全相关的综合征。
