Moon Min Hoan, Cho Jeong Yeon, Lee Yu Mi, Lee Young Ho, Yang Jae Hyug, Kim Moon Young, Park Seong Ho
Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Department of Radiology, Seoul, Republic of Korea.
Prenat Diagn. 2006 Jun;26(6):524-7. doi: 10.1002/pd.1447.
The aim of this study was to provide reference values for nasal bone length (NBL) scanned at 11-14 weeks' gestation in the Korean population and compare these values with those of the Caucasian and African-American populations.
From April 2004 to July 2004, fetal NBLs were measured in well-dated, non-anomalous fetuses at 11-14 weeks' gestation in the Korean population. Regression analysis was used to assess the relationship between NBL and crown-rump length (CRL), and reference values including the 5th, 50th, and 95th percentile were calculated for each gestational age. The reference values in our study were compared with those of the Caucasian and African-American populations.
A total of 982 cases were prospectively included in the study. NBL increased linearly with advance in CRL and was described by the equation; NBL (mm) = 0.433 + 0.022 x CRL (mm), R(2) = 0.37. The median values (5%, 95%) were 1.5 mm (1.2 mm, 1.9 mm), 1.7 mm (1.4 mm, 2.1 mm), 1.9 mm (1.6 mm, 2.3 mm), and 2.1 mm (1.7 mm, 2.6 mm) for 11, 12, 13, and 14 weeks' gestation, respectively. The median values for each gestational age in the Korean population were significantly lower than those in the Caucasian and African-American populations (P < 0.0001).
There is a difference in NBL scanned at 11-14 weeks' gestation between the Korean and the Caucasian/African-American populations, and so racial adjustment is needed in the evaluation of the fetal nasal bone for current first-trimester screening.
本研究旨在提供韩国人群妊娠11至14周时扫描的鼻骨长度（NBL）的参考值，并将这些值与白种人和非裔美国人的参考值进行比较。
2004年4月至2004年7月，对韩国人群中妊娠11至14周、孕周准确且无异常的胎儿进行NBL测量。采用回归分析评估NBL与顶臀长度（CRL）之间的关系，并计算每个孕周的第5、第50和第95百分位数的参考值。将我们研究中的参考值与白种人和非裔美国人的参考值进行比较。
本研究前瞻性纳入了982例病例。NBL随CRL增加呈线性增加，其方程为：NBL（mm）=0.433 + 0.022×CRL（mm），R² = 0.37。妊娠11、12、13和14周时的中位数（第5%，第95%）分别为1.5 mm（1.2 mm，1.9 mm）、1.7 mm（1.4 mm，2.1 mm）、1.9 mm（1.6 mm，2.3 mm）和2.1 mm（1.7 mm，2.6 mm）。韩国人群中每个孕周的中位数均显著低于白种人和非裔美国人（P < 0.0001）。
韩国人群与白种人/非裔美国人在妊娠11至14周时扫描的NBL存在差异，因此在当前孕早期筛查评估胎儿鼻骨时需要进行种族校正。
