口服硼酸摄入对体重的减轻作用。
Body weight reducing effect of oral boric acid intake.
机构信息
Department of General Surgery, Bezmialem Vakif University, Turkey.
出版信息
Int J Med Sci. 2011;8(8):653-8. doi: 10.7150/ijms.8.653. Epub 2011 Oct 21.
BACKGROUND
Boric acid is widely used in biology, but its body weight reducing effect is not researched.
METHODS
Twenty mice were divided into two equal groups. Control group mice drank standard tap water, but study group mice drank 0.28mg/250ml boric acid added tap water over five days. Total body weight changes, major organ histopathology, blood biochemistry, urine and feces analyses were compared.
RESULTS
Study group mice lost body weight mean 28.1% but in control group no weight loss and also weight gained mean 0.09% (p<0.001). Total drinking water and urine outputs were not statistically different. Cholesterol, LDL, AST, ALT, LDH, amylase and urobilinogen levels were statistically significantly high in the study group. Other variables were not statistically different. No histopathologic differences were detected in evaluations of all resected major organs.
CONCLUSION
Low dose oral boric acid intake cause serious body weight reduction. Blood and urine analyses support high glucose, lipid and middle protein catabolisms, but the mechanism is unclear.
背景
硼酸在生物学中被广泛应用，但尚未研究其减轻体重的效果。
方法
将 20 只小鼠随机分为两组，对照组小鼠饮用标准自来水，而研究组小鼠连续 5 天饮用添加 0.28mg/250ml 硼酸的自来水。比较两组的总体重变化、主要器官组织病理学变化、血液生化学、尿液和粪便分析。
结果
研究组小鼠平均体重减轻 28.1%，而对照组小鼠体重无明显减轻，反而平均增加 0.09%（p<0.001）。两组的总饮水量和尿量无统计学差异。研究组的胆固醇、LDL、AST、ALT、LDH、淀粉酶和尿胆原水平显著升高。其他变量无统计学差异。对所有切除的主要器官的评估中未发现组织病理学差异。
结论
低剂量口服硼酸摄入可导致严重的体重减轻。血液和尿液分析支持高糖、脂质和中间蛋白代谢，但机制尚不清楚。
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