Bezmialem Vakif University, ATA-2 Sitesi Akasya Caddesi No. 25 Cengelkoy, Uskudar, 80700 Istanbul, Turkey.
Int J Endocrinol. 2013;2013:914651. doi: 10.1155/2013/914651. Epub 2013 Jun 3.
Objective. The effect of oral boric acid intake on reducing body weight has been previously demonstrated although the mechanism has been unclear. This research study reveals the mechanism. Subjects. Twelve mice were used, in groups of six each in the control and study groups. For five days, control group mice drank standard tap water while during the same time period the study group mice drank tap water which contains 0.28 mg/250 mL boric acid. After a 5-day period, gene expression levels for uncoupling proteins (UCPs) in the white adipose tissue (WAT), brown adipose tissue (BAT), and skeletal muscle tissue (SMT) and total body weight changes were analyzed. Results. Real time PCR analysis revealed no significant change in UCP3 expressions, but UCP2 in WAT (P: 0.0317), BAT (P: 0.014), and SMT (P: 0.0159) and UCP1 in BAT (P: 0.026) were overexpressed in the boric acid group. In addition, mice in the boric acid group lost body weight (mean 28.1%) while mice in the control group experienced no weight loss but a slight weight gain (mean 0.09%, P < 0.001). Conclusion. Oral boric acid intake causes overexpression of thermogenic proteins in the adipose and skeletal muscle tissues. Increasing thermogenesis through UCP protein pathway results in the accelerated lipolysis and body weight loss.
目的。先前已经证明，口服硼酸摄入可以减轻体重，但具体机制尚不清楚。本研究揭示了这一机制。
对象。本研究使用了 12 只小鼠，分为对照组和实验组，每组 6 只。在 5 天的时间里，对照组小鼠饮用标准自来水，而实验组小鼠饮用含有 0.28mg/250mL 硼酸的自来水。在 5 天的时间后，分析了白色脂肪组织（WAT）、棕色脂肪组织（BAT）和骨骼肌组织（SMT）中的解偶联蛋白（UCPs）的基因表达水平和总体重变化。
结果。实时 PCR 分析显示 UCP3 表达没有显著变化，但 WAT（P：0.0317）、BAT（P：0.014）和 SMT（P：0.0159）中的 UCP2 和 BAT 中的 UCP1 的表达增加（P：0.026）。此外，硼酸组的小鼠体重减轻（平均 28.1%），而对照组的小鼠体重没有减轻，但略有增加（平均 0.09%，P < 0.001）。
结论。口服硼酸摄入会导致脂肪和骨骼肌组织中产热蛋白的过度表达。通过 UCP 蛋白途径增加产热会导致脂肪分解加速和体重减轻。
