评估 IL18 和 IL18R1 多态性：对膝骨关节炎的遗传易感性。
Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis.
机构信息
Department of Anatomy, Veterinary School, University of Bristol, Bristol, UK.
出版信息
Int J Immunogenet. 2012 Apr;39(2):106-9. doi: 10.1111/j.1744-313X.2011.01060.x. Epub 2011 Dec 4.
Abstract
We examined single-nucleotide polymorphisms (SNPs) in IL18 and IL18/R1 genes and knee OA. IL18 rs1946518 wild-type allele was more frequently observed in cases (P = 0.04). Haplotype 1 was more frequently observed in cases (P = 0.04). Genetic variation in the promoter region of IL18, but not IL18R1, may be associated with OA.
摘要
我们研究了 IL18 和 IL18/R1 基因中的单核苷酸多态性（SNPs）与膝骨关节炎（OA）的关系。IL18 rs1946518 野生型等位基因在病例中更为常见（P = 0.04）。单体型 1 在病例中更为常见（P = 0.04）。IL18 启动子区域的遗传变异，但不是 IL18R1，可能与 OA 相关。
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