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本文引用的文献

1
Surfing a genetic association interaction network to identify modulators of antibody response to smallpox vaccine.利用遗传关联交互网络来鉴定天花疫苗抗体反应的调节剂。
Genes Immun. 2010 Dec;11(8):630-6. doi: 10.1038/gene.2010.37. Epub 2010 Jul 8.
2
SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine.细胞因子和细胞因子受体基因中的 SNP/单倍型关联与风疹疫苗免疫反应。
Immunogenetics. 2010 Apr;62(4):197-210. doi: 10.1007/s00251-010-0423-6. Epub 2010 Mar 10.
3
Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels.全基因组关联研究鉴定出与白细胞介素 18 水平相关的 IL18-BCO2 基因座的变异。
Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):885-90. doi: 10.1161/ATVBAHA.109.199422. Epub 2010 Feb 11.
4
The IL-1 family: regulators of immunity.IL-1 家族：免疫调节因子。
Nat Rev Immunol. 2010 Feb;10(2):89-102. doi: 10.1038/nri2691. Epub 2010 Jan 18.
5
2'-5'-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine.2′-5′-寡聚腺苷酸合成酶单核苷酸多态性和单倍型与风疹疫苗免疫反应的变化有关。
Hum Immunol. 2010 Apr;71(4):383-91. doi: 10.1016/j.humimm.2010.01.004. Epub 2010 Jan 31.
6
A functional polymorphism in IL-18 is associated with severity of bronchial asthma.白细胞介素-18中的功能性多态性与支气管哮喘的严重程度相关。
Am J Respir Crit Care Med. 2009 Dec 1;180(11):1048-55. doi: 10.1164/rccm.200905-0652OC. Epub 2009 Sep 10.
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IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells.白细胞介素-1家族成员和信号转导及转录激活因子激活剂可诱导辅助性T细胞2、辅助性T细胞17和辅助性T细胞1产生细胞因子。
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13463-8. doi: 10.1073/pnas.0906988106. Epub 2009 Jul 29.
8
IL-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection.白细胞介素-12p40和白细胞介素-18在协调针对痘病毒感染的细胞介导免疫反应中起关键作用。
J Immunol. 2009 Sep 1;183(5):3324-31. doi: 10.4049/jimmunol.0803985. Epub 2009 Aug 5.
9
The candidate gene approach in asthma: what happens with the neighbours?哮喘研究中的候选基因方法：其邻近基因会怎样？
Eur J Hum Genet. 2010 Jan;18(1):17; author reply 17-8. doi: 10.1038/ejhg.2009.128.
10
The immunology of smallpox vaccines.天花疫苗的免疫学
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白种人和非裔美国人中 IL18R1 和 IL18 基因的常见 SNP/单倍型与天花疫苗接种后的体液免疫变化有关。

Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in humoral immunity to smallpox vaccination in Caucasians and African Americans.

机构信息

Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA.

出版信息

J Infect Dis. 2011 Aug 1;204(3):433-41. doi: 10.1093/infdis/jir268.

DOI:10.1093/infdis/jir268
PMID:21742843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3132141/
Abstract

BACKGROUND

Identifying genetic factors that influence poxvirus immunity across races may assist in the development of better vaccines and approaches for vaccine development.

METHODS

We performed an extensive candidate-gene genetic screen (across 32 cytokine and cytokine receptor genes) in a racially diverse cohort of 1056 healthy adults after a single dose of smallpox vaccine. Associations between single-nucleotide polymorphisms (SNPs)/haplotypes and vaccinia virus-specific neutralizing antibodies were assessed using linear regression methodologies.

RESULTS

The combined analysis identified 63 associations between candidate SNPs and antibody levels after smallpox vaccination with P < .05. Thirty-one of these were within the IL18R1 and IL18 genes. Five IL18R1 SNPs, including a coding synonymous polymorphism rs1035130 (Phe251Phe) and 2 promoter SNPs (rs6710885, rs2287037), all in linkage disequilibrium, were associated with significant variations in antibody levels in both Caucasians (P ≤ .016) and African Americans (P ≤ .025). Similarly, associations with 2 intronic IL18 SNPs (rs2043055 and rs5744280) were consistent in the Caucasian (P ≤ .023) and African American samples (P ≤ .014). Haplotype analysis revealed highly significant associations between IL18R1 haplotypes and vaccinia virus-specific antibody levels (P < .001, by combined analysis) that were consistent across races.

CONCLUSIONS

Our study provides evidence for IL18 and IL18R1 genes as plausible genes regulating the humoral immune response to smallpox vaccine in both Caucasians and African Americans.

摘要

背景

鉴定影响不同种族人群痘病毒免疫的遗传因素，可能有助于开发更好的疫苗和疫苗开发方法。

方法

我们在接种一剂天花疫苗后的 1056 名种族多样化的健康成年人中，进行了广泛的候选基因遗传筛选（涉及 32 种细胞因子和细胞因子受体基因）。使用线性回归方法评估单核苷酸多态性（SNP）/单倍型与痘苗病毒特异性中和抗体之间的关联。

结果

综合分析确定了 63 个候选 SNP 与天花疫苗接种后抗体水平之间的关联，P 值均小于 0.05。其中 31 个 SNP 位于 IL18R1 和 IL18 基因内。IL18R1 的 5 个 SNP，包括一个编码同义多态性 rs1035130（Phe251Phe）和 2 个启动子 SNP（rs6710885、rs2287037），均处于连锁不平衡状态，与白种人和非裔美国人的抗体水平显著相关（P ≤ 0.016 和 P ≤ 0.025）。同样，IL18 基因的 2 个内含子 SNP（rs2043055 和 rs5744280）与白种人和非裔美国人样本中的关联一致（P ≤ 0.023 和 P ≤ 0.014）。单体型分析显示，IL18R1 单体型与天花病毒特异性抗体水平之间存在高度显著的关联（P < 0.001，综合分析），且在不同种族中一致。

结论

本研究为 IL18 和 IL18R1 基因作为调节白种人和非裔美国人对天花疫苗的体液免疫反应的潜在基因提供了证据。