阿克莫司他，一种来自海洋真菌节菱孢的高度氧化代谢产物。

Acremostrictin, a highly oxygenated metabolite from the marine fungus Acremonium strictum.

机构信息

Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.

出版信息

J Nat Prod. 2011 Dec 27;74(12):2592-4. doi: 10.1021/np200707y. Epub 2011 Dec 2.

DOI:10.1021/np200707y

PMID:22136576

Abstract

The novel natural product acremostrictin was isolated from the culture broth of Acremonium strictum, a marine fungus collected from a Choristida sponge off the coast of Korea. Structurally, acremostrictin is a tricyclic lactone of an unprecedented skeletal class based on combined spectroscopic and X-ray crystallographic analyses. The new compound exhibited weak antibacterial and moderate antioxidant activities.

摘要

新型天然产物 acremostrictin 是从海洋真菌棘孢小克银汉霉（Acremonium strictum）的发酵液中分离得到的，该真菌是从韩国海岸的一种拟海龙科海绵中分离得到的。结构上，acremostrictin 是一种三环内酯，具有前所未有的骨架类型，基于综合光谱和 X 射线晶体学分析。该新化合物表现出微弱的抗菌活性和适度的抗氧化活性。