通过 2-(2,2-二溴乙烯基)苯酚与多氟芳烃的铜（I）催化反应合成 2-(多氟芳基)苯并呋喃。

Synthesis of 2-(polyfluoroaryl)benzofurans via a copper(I)-catalyzed reaction of 2-(2,2-dibromovinyl)phenol with polyfluoroarene.

机构信息

Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.

出版信息

Org Lett. 2012 Jan 6;14(1):70-3. doi: 10.1021/ol202858f. Epub 2011 Dec 2.

DOI:10.1021/ol202858f

Abstract

A novel and efficient route for the synthesis of 2-(polyfluoroaryl)benzofurans via a copper(I)-catalyzed tandem reaction of 2-(2,2-dibromovinyl)phenol with polyfluoroarene is reported. The corresponding products are generated in good yields. During the reaction process, a copper-catalyzed intramolecular C-O bond formation and a C-H activation are involved.

摘要

本文报道了一种通过铜（I）催化 2-（2,2-二溴乙烯基）苯酚与多氟芳烃的串联反应合成 2-（多氟芳基）苯并呋喃的新颖、高效方法。该方法具有良好的产率。在反应过程中，涉及铜催化的分子内 C-O 键形成和 C-H 活化。