Minamisawa T, Hirokaga K, Sasaki S
Department of Biology, Yamanashi Medical College.
J Radiat Res. 1990 Jun;31(2):214-8. doi: 10.1269/jrr.31.214.
Gross morphological changes of the brains of first generation (F1) C57BL/6 x C3H hybrid male mice irradiated prenatally were studied at 6 months of age. Gravid female mice were irradiated with 1.0 Gy, 2.0 Gy or 3.0 Gy of gamma radiation on the 14th day of gestation. The brain in dorsal view was photographed. The measurements of the area and the distance of parts of the brain were made from photographs, using a computer system for biological image analysis. The body and brain weight and the area and length of the cerebral hemispheres (CHs) showed dose-related decrease. There was a dose related increase in the area of the superior colliculi (SC), the distance (DP) from the point which the medial walls of the CHs begin to slope away from the midline to the posterior end of CHs, and the proportion of the DP to the CH length. From the results of the dose-response curve, it appears that the area of the SC and the proportion of DP to CH length are affected by small doses of less than 1.0 Gy.
对孕期接受辐射的第一代（F1）C57BL/6×C3H杂交雄性小鼠在6月龄时大脑的大体形态变化进行了研究。妊娠雌性小鼠在妊娠第14天接受1.0 Gy、2.0 Gy或3.0 Gy的γ射线照射。拍摄大脑背视图照片。使用生物图像分析计算机系统从照片上对大脑各部分的面积和距离进行测量。身体和大脑重量以及大脑半球（CHs）的面积和长度呈剂量相关下降。上丘（SC）面积、CHs内侧壁开始从中线倾斜处到CHs后端的距离（DP）以及DP与CH长度的比例呈剂量相关增加。从剂量反应曲线结果来看，似乎SC面积以及DP与CH长度的比例受到小于1.0 Gy的小剂量影响。
