Minamisawa T, Hirokaga K
Department of Biology, Yamanshi Medical University, Japan.
J Radiat Res. 1995 Sep;36(3):179-84. doi: 10.1269/jrr.36.179.
The spontaneous circadian motor activity of first generation (F1) hybrid male C57BL/6xC3H mice irradiated with gamma rays on the 14th day of gestation was studied at the following ages: young (6-7 months), adult (12-13 months), and old (19-20 months). Doses were 0.1, 0.2, 0.5 or 1.0 Gy. A 12-hour day-night cycle was maintained with light on a at 6:00 hr. Spontaneous circadian motor activity was recorded with a capacitance-induction motility monitor for 48 consecutive hours. Activity was measured at 2-hour intervals, and the data stored on computer discs. The activity of the 1.0 Gy group recorded at 22:00 and 2:00 hr for young mice and at 2:00 hr for adult ones was significantly higher than that of the age-matched control group. Results suggest that male mice irradiated with 1.0 Gy at gestational day 14 show nocturnal hyperactivity in the young and adult stages.
对妊娠第14天接受γ射线照射的第一代（F1）杂交雄性C57BL/6xC3H小鼠，在以下年龄段研究其自发昼夜运动活动：幼年（6 - 7个月）、成年（12 - 13个月）和老年（19 - 20个月）。剂量分别为0.1、0.2、0.5或1.0 Gy。维持12小时昼夜循环，6:00开灯。用电容感应运动监测仪连续48小时记录自发昼夜运动活动。每隔2小时测量一次活动，并将数据存储在计算机磁盘上。幼年小鼠在22:00和2:00记录的1.0 Gy组活动，以及成年小鼠在2:00记录的活动，显著高于同龄对照组。结果表明，妊娠第14天接受1.0 Gy照射的雄性小鼠在幼年和成年阶段表现出夜间活动亢进。
