Pouly J-L, Darai E, Yazbeck C, Benifla J-L, Dechaud H, Wattiez A, Crowe A, Audebert A
Unité de FIV, pôle gynécologie-obstétrique et reproduction humaine, CHU Estaing, 1 place Lucie-Aubrac, Clermont-Ferrand, France.
Gynecol Obstet Fertil. 2012 Jul-Aug;40(7-8):419-28. doi: 10.1016/j.gyobfe.2011.10.001. Epub 2011 Dec 1.
This paper is the second of a two-part publication. The initial paper provided a comprehensive overview of the evidence on adhesions to allow gynaecological surgeons to be best informed on adhesions, their development, impact on patients, health systems and surgical outcomes. There is rising evidence that surgeons can take important steps to reduce the burden of adhesions. In this second paper, we review the various strategies to reduce the impact of adhesions, improve surgical outcomes and provide some practical proposals for action on adhesions. As well as improvements in surgical technique, developments in adhesion-reduction strategies and new agents offer a realistic possibility of reducing adhesion formation and improving outcomes for patients. They should be considered for use particularly in high-risk surgery and in patients with adhesiogenic conditions. Further research into new strategies to prevent adhesions more effectively through an improved surgical environment, new and combination devices and pharmacological agents should be encouraged. Formal recommendations would ensure better prioritisation of adhesion-reduction within the French health system. Patients should also be better informed of the risks of adhesions.
本文是一篇分两部分发表的论文中的第二篇。第一篇论文全面概述了有关粘连的证据,以使妇科外科医生能够充分了解粘连情况、其形成过程、对患者、卫生系统及手术结果的影响。越来越多的证据表明,外科医生可以采取重要措施来减轻粘连负担。在这第二篇论文中,我们回顾了减轻粘连影响、改善手术结果的各种策略,并就粘连问题提出了一些实际行动建议。除了手术技术的改进,粘连减轻策略的发展以及新药物为减少粘连形成和改善患者预后提供了切实可行的可能性。尤其在高风险手术和具有粘连形成倾向的患者中,应考虑使用这些方法。应鼓励进一步研究通过改善手术环境、新型及组合器械和药物制剂更有效地预防粘连的新策略。正式的建议将确保在法国卫生系统内更合理地优先考虑减轻粘连问题。还应让患者更好地了解粘连风险。