CXCL12：通过人类遗传学发现的冠心病新靶点。
CXCL12: a new player in coronary disease identified through human genetics.
机构信息
Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.
出版信息
Trends Cardiovasc Med. 2010 Aug;20(6):204-9. doi: 10.1016/j.tcm.2011.08.002.
Abstract
Genome-wide association studies (GWAS) of more than 100,000 people have revealed novel loci associated with coronary artery disease and myocardial infarction that present exciting opportunities to discover novel disease pathways. One such recently identified locus is on chromosome 10q11, near the gene for the chemokine CXCL12, which has been implicated in cardiovascular disease in both mouse and human studies. These GWAS demonstrate that CXCL12 may emerge as a potential therapeutic target for atherosclerosis and thrombosis.
摘要
全基因组关联研究（GWAS）对超过 10 万人的研究揭示了与冠心病和心肌梗死相关的新基因座，为发现新的疾病途径提供了令人兴奋的机会。最近发现的一个基因座位于 10 号染色体 q11 上，靠近趋化因子 CXCL12 的基因，该基因在小鼠和人类研究中均与心血管疾病有关。这些 GWAS 表明，CXCL12 可能成为动脉粥样硬化和血栓形成的潜在治疗靶点。
相似文献
1
CXCL12: a new player in coronary disease identified through human genetics.CXCL12：通过人类遗传学发现的冠心病新靶点。
Trends Cardiovasc Med. 2010 Aug;20(6):204-9. doi: 10.1016/j.tcm.2011.08.002.
2
CXCL12 Derived From Endothelial Cells Promotes Atherosclerosis to Drive Coronary Artery Disease.源自内皮细胞的CXCL12促进动脉粥样硬化以引发冠状动脉疾病。
Circulation. 2019 Mar 5;139(10):1338-1340. doi: 10.1161/CIRCULATIONAHA.118.037953.
3
Smooth Muscle Specific Ablation of CXCL12 in Mice Downregulates CXCR7 Associated with Defective Coronary Arteries and Cardiac Hypertrophy.在小鼠中特异性消融 CXCL12 下调 CXCR7 与冠状动脉缺陷和心脏肥大相关。
Int J Mol Sci. 2021 May 31;22(11):5908. doi: 10.3390/ijms22115908.
4
The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels.10q11 上的新动脉粥样硬化位点调节血浆 CXCL12 水平。
Eur Heart J. 2011 Apr;32(8):963-71. doi: 10.1093/eurheartj/ehr091. Epub 2011 Mar 17.
5
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.鉴定 ADAMTS7 为冠状动脉粥样硬化的新位点，以及在存在冠状动脉粥样硬化的情况下 ABO 与心肌梗死的关联：两项全基因组关联研究。
Lancet. 2011 Jan 29;377(9763):383-92. doi: 10.1016/S0140-6736(10)61996-4. Epub 2011 Jan 14.
6
A genome-wide association study reveals susceptibility loci for myocardial infarction/coronary artery disease in Saudi Arabs.一项全基因组关联研究揭示了沙特阿拉伯人心肌梗死/冠状动脉疾病的易感性位点。
Atherosclerosis. 2016 Feb;245:62-70. doi: 10.1016/j.atherosclerosis.2015.11.019. Epub 2015 Nov 22.
7
Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease.基因变异导致的RGS5下调会损害内皮细胞功能并促成冠状动脉疾病。
Cardiovasc Res. 2021 Jan 1;117(1):240-255. doi: 10.1093/cvr/cvz268.
8
Genome-wide association studies of late-onset cardiovascular disease.迟发性心血管疾病的全基因组关联研究。
J Mol Cell Cardiol. 2015 Jun;83:131-41. doi: 10.1016/j.yjmcc.2015.04.004. Epub 2015 Apr 11.
9
CXCL12 drives natural variation in coronary artery anatomy across diverse populations.CXCL12驱动不同人群冠状动脉解剖结构的自然变异。
Cell. 2025 Apr 3;188(7):1784-1806.e22. doi: 10.1016/j.cell.2025.02.005. Epub 2025 Mar 5.
10
Stromal cell-derived factor-1-3'A polymorphism is associated with decreased risk of myocardial infarction and early endothelial disturbance.基质细胞衍生因子-1-3'A多态性与心肌梗死风险降低及早期内皮功能紊乱相关。
J Cardiovasc Med (Hagerstown). 2014 Sep;15(9):710-6. doi: 10.2459/JCM.0000000000000068.
引用本文的文献
1
Peripheral inflammatory response in people after acute ischaemic stroke and isolated spontaneous cervical artery dissection.急性缺血性脑卒中后和孤立性自发性颈内动脉夹层患者的外周炎症反应。
Sci Rep. 2024 May 27;14(1):12063. doi: 10.1038/s41598-024-62557-3.
2
Investigating the therapeutic effects and mechanisms of Carthamus tinctorius L.-derived nanovesicles in atherosclerosis treatment.研究红花衍生纳米囊泡在动脉粥样硬化治疗中的治疗效果和作用机制。
Cell Commun Signal. 2024 Mar 12;22(1):178. doi: 10.1186/s12964-024-01561-6.
3
Mental Stress-Induced Change in Plasma Stromal Cell-Derived Factor-1 and Adverse Cardiovascular Outcomes: A Cohort Study.精神压力诱导血浆基质细胞衍生因子-1变化与不良心血管结局：一项队列研究
CJC Open. 2023 Jan 28;5(4):325-332. doi: 10.1016/j.cjco.2023.01.006. eCollection 2023 Apr.
4
Correlations Between Serum CXCL9/12 and the Severity of Acute Ischemic Stroke, a Retrospective Observational Study.血清CXCL9/12与急性缺血性卒中严重程度的相关性：一项回顾性观察研究
Neuropsychiatr Dis Treat. 2023 Jan 29;19:283-292. doi: 10.2147/NDT.S391578. eCollection 2023.
5
Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice.巨噬细胞特异性 IGF-1 过表达降低了 Apoe 缺陷小鼠的趋化因子 CXCL12 水平并抑制动脉粥样硬化负担。
Arterioscler Thromb Vasc Biol. 2022 Feb;42(2):113-126. doi: 10.1161/ATVBAHA.121.316090. Epub 2021 Dec 2.
6
Role and implications of the CXCL12/CXCR4/CXCR7 axis in atherosclerosis: still a debate.CXCL12/CXCR4/CXCR7 轴在动脉粥样硬化中的作用和意义：仍存在争议。
Ann Med. 2021 Dec;53(1):1598-1612. doi: 10.1080/07853890.2021.1974084.
7
Polydatin Reduces Cardiotoxicity and Enhances the Anticancer Effects of Sunitinib by Decreasing Pro-Oxidative Stress, Pro-Inflammatory Cytokines, and NLRP3 Inflammasome Expression.虎杖苷通过降低促氧化应激、促炎细胞因子和NLRP3炎性小体表达减轻舒尼替尼的心脏毒性并增强其抗癌作用。
Front Oncol. 2021 Jun 11;11:680758. doi: 10.3389/fonc.2021.680758. eCollection 2021.
8
Smooth Muscle Specific Ablation of CXCL12 in Mice Downregulates CXCR7 Associated with Defective Coronary Arteries and Cardiac Hypertrophy.在小鼠中特异性消融 CXCL12 下调 CXCR7 与冠状动脉缺陷和心脏肥大相关。
Int J Mol Sci. 2021 May 31;22(11):5908. doi: 10.3390/ijms22115908.
9
Inflammation-Related Risk Loci in Genome-Wide Association Studies of Coronary Artery Disease.与冠状动脉疾病的全基因组关联研究相关的炎症相关风险基因座。
Cells. 2021 Feb 19;10(2):440. doi: 10.3390/cells10020440.
10
Radiation-induced cardiovascular disease: an overlooked role for DNA methylation?辐射诱导的心血管疾病：DNA 甲基化被忽视的作用？
Epigenetics. 2022 Jan;17(1):59-80. doi: 10.1080/15592294.2021.1873628. Epub 2021 Jan 31.
本文引用的文献
1
The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels.10q11 上的新动脉粥样硬化位点调节血浆 CXCL12 水平。
Eur Heart J. 2011 Apr;32(8):963-71. doi: 10.1093/eurheartj/ehr091. Epub 2011 Mar 17.
2
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.一项在欧洲人和南亚人群中进行的全基因组关联研究确定了五个新的冠心病发病位点。
Nat Genet. 2011 Mar 6;43(4):339-44. doi: 10.1038/ng.782.
3
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.鉴定 ADAMTS7 为冠状动脉粥样硬化的新位点，以及在存在冠状动脉粥样硬化的情况下 ABO 与心肌梗死的关联：两项全基因组关联研究。
Lancet. 2011 Jan 29;377(9763):383-92. doi: 10.1016/S0140-6736(10)61996-4. Epub 2011 Jan 14.
4
Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis.10 号染色体上与冠状动脉疾病相关的遗传变异与颈动脉内膜中层厚度和动脉粥样硬化有关。
Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2678-83. doi: 10.1161/ATVBAHA.110.213785. Epub 2010 Sep 16.
5
Platelet-derived chemokines in vascular remodeling and atherosclerosis.血小板衍生趋化因子在血管重构和动脉粥样硬化中的作用。
Semin Thromb Hemost. 2010 Mar;36(2):163-9. doi: 10.1055/s-0030-1251500. Epub 2010 Apr 22.
6
Chemokines in the vascular inflammatory response of atherosclerosis.趋化因子在动脉粥样硬化血管炎症反应中的作用。
Cardiovasc Res. 2010 May 1;86(2):192-201. doi: 10.1093/cvr/cvp391. Epub 2009 Dec 9.
7
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.早发性心肌梗死与单核苷酸多态性和拷贝数变异的全基因组关联研究
Nat Genet. 2009 Mar;41(3):334-41. doi: 10.1038/ng.327. Epub 2009 Feb 8.
8
Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells.急性冠状动脉综合征患者循环血小板上基质细胞衍生因子-1的表达增加，且与CD34+祖细胞数量相关。
Eur Heart J. 2009 Mar;30(5):584-93. doi: 10.1093/eurheartj/ehn566. Epub 2008 Dec 24.
9
Chemokines and cardiovascular risk.趋化因子与心血管风险。
Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):1909-19. doi: 10.1161/ATVBAHA.107.161240. Epub 2008 Jul 31.
10
Chemokines in atherosclerosis: an update.动脉粥样硬化中的趋化因子：最新进展
Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):1897-908. doi: 10.1161/ATVBAHA.107.161174. Epub 2008 Jun 19.
Zotero 插件