Department of Pharmaceutical Botany, Faculty of Pharmacy, Ankara University, Tandoğan 06100, Ankara, Turkey.
J Ethnopharmacol. 2012 Jan 31;139(2):401-8. doi: 10.1016/j.jep.2011.11.024. Epub 2011 Nov 25.
The leaves of Michauxia species are used for the treatment of wounds in Turkish traditional medicine. In the present study, wound healing, anti-inflammatory and antioxidant activities of the extracts obtained from the root and herb of 5 species of Michauxia collected in different parts of Turkey were evaluated.
In vivo incision and excision wound models were used in order to assess the wound healing effects of the methanolic extracts of the plants. Skin samples were also evaluated histopathologically. In vivo inhibitory effect of the extracts on acetic acid-induced increase in capillary permeability was studied for the assessment of anti-inflammatory activity. TBA (thiobarbituric acid) test, qualitative and quantitative DPPH (2,2-diphenyl-1-picrylhydrazyl) tests were used to evaluate the antioxidant activity.
Noteworthy wound healing activity was observed for the ointment formulation prepared with 1% Michauxia nuda (root) and Michauxia tchihatchewii (herb) extracts. The results of histopathological evaluation supported the outcome of incision and excision wound models. Moreover, the Michauxia nuda (root) exerted remarkable anti-inflammatory effect. The highest antioxidant activity was observed with the ethyl acetate extract of Michauxia tchihatchewii herb.
The experimental study revealed that Michauxia displays remarkable wound healing and anti-inflammatory and antioxidant activities.
土耳其传统医学中，使用 Michauxia 属植物的叶子来治疗伤口。在本研究中，评估了从土耳其不同地区采集的 5 种 Michauxia 植物的根和草部分提取的提取物的伤口愈合、抗炎和抗氧化活性。
为了评估植物甲醇提取物的伤口愈合作用，采用体内切口和切除伤口模型。还对皮肤样本进行了组织病理学评估。为了评估抗炎活性，研究了提取物对醋酸诱导的毛细血管通透性增加的体内抑制作用。使用 TBA（硫代巴比妥酸）试验、定性和定量 DPPH（2,2-二苯基-1-苦基肼）试验评估抗氧化活性。
Michauxia nuda（根）和 Michauxia tchihatchewii（草）提取物 1%软膏制剂表现出显著的伤口愈合活性。组织病理学评估结果支持切口和切除伤口模型的结果。此外，Michauxia nuda（根）表现出显著的抗炎作用。Michauxia tchihatchewii 草的乙酸乙酯提取物表现出最高的抗氧化活性。
实验研究表明，Michauxia 具有显著的伤口愈合、抗炎和抗氧化活性。
