Department of Chemistry and Biochemistry, University of San Diego, 5998 Alcala Park, San Diego, CA 92110, USA.
Orig Life Evol Biosph. 2011 Dec;41(6):553-8. doi: 10.1007/s11084-011-9250-5. Epub 2011 Dec 3.
We examine the stability of three key components needed to establish an RNA World under a range of potential conditions present on the early earth. The stability of ribose, cytosine, and the phosphodiester bond are estimated at different pH values and temperatures by extrapolating available experimental data. The conditions we have chosen range from highly acidic or alkaline hydrothermal vents, to the milder conditions in a primordial ocean at a range of atmospheric CO(2) partial pressures.
我们研究了在早期地球上存在的一系列潜在条件下,建立 RNA 世界所需的三个关键成分的稳定性。通过推断可用的实验数据,我们在不同的 pH 值和温度下估计了核糖、胞嘧啶和磷酸二酯键的稳定性。我们选择的条件范围从高度酸性或碱性的热液喷口,到原始海洋中在不同大气 CO(2)分压下的较温和条件。